Effects of cisapride on ventricular depolarization-repolarization and arrhythmia markers in infants

Article Article scientifique Article Effects of cisapride on ventricular depolarization-repolarization and arrhythmia markers in infants eng 2001 author Zamora Samuel Antonio 32965 author Belli Dominique Charles 26369 author Ferrazzini Giovanna 514398 author Friedli Beat 25332 30-34 10.1159/000047116 11474146 0006-3126 To study prospectively the effects of cisapride on ventricular repolarization, depolarization, and arrhythmia markers in neonates, we determined before and three days after starting cisapride (1 mg/kg/day): corrected QT interval (QTc) and QT dispersion (QTd) on standard ECGs, and duration of filtered QRS (fQRS) and of low amplitude (<40 microV) terminal signals (LAS40, ms) and root mean square of the last 40 ms (RMS40, microV) using high-gain signal-averaged ECG (SAECG). Twenty-four term and 11 preterm infants (gestational age 23-35 weeks) were studied at a median chronological age of 32 days. QTc and QTd were not different between term and preterm infants. Cisapride lengthened QTc (mean +/- SD; ms: 396.6 +/- 24.8 before vs. 417.0 +/- 35.2 after, p < 0.001). Three term and two preterm infants (5/35 = 14%; 95% CI: 5-30%) had a QTc >450 ms after cisapride. QTd after cisapride increased significantly in all infants with prolonged QTc. Filtered QRS, LAS40, and RMS40 before and after cisapride were within our normal values. We conclude that cisapride prolongs ventricular repolarization in neonates and infants without altering depolarization. Although no clinical arrhythmias were observed the dose of 0.8 mg/kg/day should not be exceeded. Arrhythmias, Cardiac/chemically induced/physiopathology Biological Markers Cisapride/administration & dosage/adverse effects Electrocardiography Electrophysiology Gastroesophageal Reflux/drug therapy Gastrointestinal Agents/administration & dosage/adverse effects Gestational Age Heart/drug effects Heart Ventricles/drug effects/physiopathology Humans Infant Infant, Newborn Infant, Premature Prospective Studies Reference Values Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 147 Gastroentérologie et transplantation (pédiatrie) 181 Biology of the neonate 80 1 9549f737-1a9e-4672-8302-fe09a0c00a0a Article (Published version) Restricted 30-34.pdf 172547 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Title	Published in	Year	Views	Downloads

Effects of cisapride on ventricular depolarization-repolarization and arrhythmia markers in infants	Biology of the neonate	2001	435	0
Méningite à streptocoque β-hémolytique du groupe A chez une femme enceinte = Group A streptococcal meningitis in a pregnant woman	Schweizerische medizinische Wochenschrift	1996	354	137

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Ferrazzini, Giovanna