Dementia prevention in memory clinics : recommendations from the european task force for brain health services

Article Article scientifique Revue de la littérature Dementia prevention in memory clinics : recommendations from the european task force for brain health services eng 2023-01-31 2023-03 author Frisoni Giovanni Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland. 810190 dept de réadaptation et gériatrie (MIGRG) author Altomare Daniele Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland. 917820 author Ribaldi Federica Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland. 920118 dept de réadaptation et gériatrie (MIGRG) author Villain Nicolas 0000-0002-7429-4289 Institut de la Mémoire et de la Maladie d'Alzheimer, IM2A, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.,Institut du Cerveau et de la Moelle Épinière, UMR-S975, INSERM, Paris, France. author Brayne Carol Cambridge Public Health, University of Cambridge, Cambridge, UK. author Mukadam Naaheed Division of Psychiatry, University College London, London, UK. author Abramowicz Marc Genetic Medicine, Diagnostics Dept, University Hospitals and University of Geneva, Geneva, Switzerland. 884432 Département de médecine génétique et développement (GEDEV) author Barkhof Frederik 0000-0003-3543-3706 Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.,Queen Square Institute of Neurology, University College London, London, UK. author Berthier Marcelo Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, Malaga, Spain. author Bieler-Aeschlimann Melanie Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.,Infections Disease Service, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. author Blennow Kaj Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden. author Brioschi Andréa Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.,Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland. 507514 Section de psychologie (PSICO) author Carrera Emmanuel Stroke Center, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland. 812606 Département des neurosciences cliniques (OTONO) author Chételat Gaël Normandie University, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France. author Csajka Chantal Center of Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital and University of Lausanne, Lausanne, Switzerland. author Demonet Jean-François Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.,French Clinical Research Infrastructure Network, INSERM, University Hospital of Toulouse, France. author Dodich Alessandra 0000-0001-9140-0699 Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy. author Garibotto Valentina 0000-0003-2422-698X Division of Nuclear Medicine and Molecular Imaging, University Hospitals of Geneva and NIMTLab, University of Geneva, Geneva, Switzerland. 704817 Département de radiologie et informatique médicale (RADIO) author Georges Jean Alzheimer Europe, Luxembourg. author Hurst Samia 0000-0002-1980-5226 Institute for Ethics, History, and the Humanities, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 84281 iEH2 (COETH) author Jessen Frank Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.,German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.,Excellence Cluster Cellular Stress Responses in Aging-Related Diseases (CECAD), Medical Faculty, University of Cologne, Germany. author Kivipelto Miia Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.,Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.,Theme Aging, Karolinska University Hospital, Stockholm, Sweden.,The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK. author Llewellyn David J College of Medicine and Health, University of Exeter, UK.,Alan Turing Institute, Exeter, UK. author McWhirter Laura Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK. author Milne Richard 0000-0002-8770-2384 Cambridge Public Health, University of Cambridge, Cambridge, UK.,Engagement and Society, Wellcome Connecting Science, Hinxton, UK. author Minguillón Carolina Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.,CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. author Miniussi Carlo 0000-0002-5436-4745 Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy.,Centre for Medical Sciences (CISMed), University of Trento, Rovereto, Italy. author Molinuevo José Luis Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.,H. Lundbeck A/S, Denmark. author Nilsson Peter M Department of Clinical Science, Lund University, Sweden.,Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden. author Noyce Alastair Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK. author Ranson Janice M College of Medicine and Health, University of Exeter, UK. author Grau-Rivera Oriol Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. author Schott Jonathan M Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK. author Solomon Alina Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.,Division of Clinical Geriatrics, NVS, Karolinska Institutet, Stockholm, Sweden.,The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK. author Stephen Ruth 0000-0002-3380-9530 Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. author van der Flier Wiesje Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands.,Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.,Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands. author van Duijn Cornelia Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.,Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. author Vellas Bruno Gerontopole and Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France. author Visser Leonie N C 0000-0003-3487-7938 Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.,Department of Medical Psychology, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands. author Cummings Jeffrey L Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, USA. author Scheltens Philip Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands.,EQT Life Sciences, Amsterdam, the Netherlands. author Ritchie Craig Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. author Dubois Bruno Institut de la Mémoire et de la Maladie d'Alzheimer, IM2A, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.,Institut du Cerveau et de la Moelle Épinière, UMR-S975, INSERM, Paris, France. 100576 10.1016/j.lanepe.2022.100576 36895446 2666-7762 PMC9989648 https://www.sciencedirect.com/science/article/pii/S2666776222002721 Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment. Cognitive enhancement Dementia Memory clinic Prevention Risk assessment Risk communication Risk reduction Dewey 616.8 Dewey 174.957 Dewey 616.0757 Dewey 150 Dewey 618.97 Dewey 576.5 Swiss National Science Foundation Dementia Prevention Services 193593 CH Science communication Swiss National Science Foundation CLearing Alzheimer’s disease Molecular Pathology without medications (CLAMP) 196354 CH Projects Swiss National Science Foundation Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): correlation with clinical features and in vivo neuropathology 182772 CH Projects 65 Département de réadaptation et gériatrie 22B 135 Département de médecine génétique et développement 21D 108 Section de psychologie 71 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 69 Institut Ethique Histoire Humanités 22A6 false 853 Troubles de mémoire et maladie d'Alzeimer 935 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 1297 Abramowicz Lab 1013 1416 Accident vasculaire cérébral 1049 453 Ethique biomédicale 783 The Lancet regional health. Europe 26 139f4053-cc56-4292-94e3-3d6195ceab78 Article (Published version) Public Article-scientifique-from-europePmc.pdf 900271 application/pdf CC BY-4.0 fd737624278251f66f18bd683f0aaadbee7951648b99bd9a375392c4d6c2976e 00732cab-875b-4f2f-a801-822462793a0c Appendix Public mmc1.docx 655328 application/vnd.openxmlformats-officedocument.wordprocessingml.document 40940f1ed98719073cae07c3592afe4287fd6d7df24ba839493d1d9ef01c03d0 openAccess Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de psychologie et des sciences de l'éducation / Section de psychologie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut Ethique Histoire Humanités

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Dementia prevention in memory clinics : recommendations from the european task force for brain health services	The Lancet regional health. Europe			2023	123	288

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Brioschi, Andréa