Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck

Article Article scientifique Article Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck eng 2004 author Mhawech-fauceglia Paulette 549956 Paulette Mhawech-Fauceglia author Dulguerov Pavel 0000-0001-5863-3933 28772 author Tschanz Elisabeth 583199 author Verdan Caroline 506031 author Ares C author Allal Abdelkarim Said 130470 471-475 10.1038/sj.bjc.6601542 14735195 0007-0920 CD9 is a transmembrane protein that has been implicated in cell adhesion, motility and proliferation, and numerous studies have demonstrated the prognostic value of its expression in different solid tumours. The purpose of this study is to determine the predictive value of CD9 in squamous cell carcinoma (SCC) of the head and neck. A total of 153 cases were examined for CD9 expression using immunohistochemistry applied on formalin-fixed, paraffin-embedded tissue. Cases were stratified in two categories depending on CD9 expression, as positive (>/=50% positive cells) or reduced (<50%). In all, 108 cases were positive for CD9 (85 cases with membranous, and 23 with both membranous and cytoplasmic staining) and 45 reduced expression. Reduced CD9 expression was significantly associated with high grade (P=0.0007) and lower disease-free survival (DFS) (P=0.017). The latter retained its significance in the multivariate analysis. When the 23 cases with both membranous and cytoplasmic patterns were studied as a separate subgroup, there were significant associations between CD9 expression and tumour grade (P=0.025) (95% CI 11-68), tumour stage (P=0.08) (95% CI 3.5-86) and the occurrence of any failure (P=0.083) (95% CI -1.7-57). Immunohistochemical CD9 expression proved to be an independent prognostic factor in SCC of the head and neck, and it may detect patients at a high risk of recurrence. In addition, the cytoplasmic pattern seems to have an even more significant value. However, this finding is limited to the small number of cases with this pattern. Adult Aged Aged, 80 and over Antigens, CD/biosynthesis Antigens, CD9 Carcinoma, Squamous Cell/pathology DNA, Neoplasm Disease-Free Survival Female Gene Expression Regulation, Neoplastic Head and Neck Neoplasms/pathology Humans Immunohistochemistry Male Membrane Glycoproteins/biosynthesis Middle Aged Neoplasm Recurrence, Local Prognosis Retrospective Studies Risk Factors Dewey 616.8 61 Département des neurosciences cliniques 226 false 116 Groupe Dulguerov Pavel (ORL et chirurgie cervico-faciale) 145 British journal of cancer 90 2 6ea4b541-cf48-475b-b173-73869de08f31 Article (Published version) Public 2004 Mhawech - Br J Cancer - MRP.pdf 235498 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Motility-related protein-1 (MRP-1/CD9) expression can predict disease-free survival in patients with squamous cell carcinoma of the head and neck	British journal of cancer			2004	635	329

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Verdan, Caroline