HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity

Article Article scientifique Article HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity eng 2001 author Renquin Johan 502613 author Sanchez-Mazas Alicia 22545 author Halle L. author Rivalland S. author Jaeger G. author Mbayo K. author Bianchi F. author Kaplan C. 211-222 10.1034/j.1399-0039.2001.580401.x 11782272 0001-2815 HLA-DRB1, -DQB1 and -DPB1 polymorphisms were investigated in two African populations, the Basse Lobaye Aka Pygmies of the Central African Republic, and a Bantu-speaking group from the Democratic Republic of Congo Kinshasa. Allelic and haplotypic frequency distributions reveal marked differences between the two populations in spite of their geographical proximity: the Aka exhibit high frequencies for several alleles, especially at the DPB1 locus (0.695 for DPB1*0402), probably due to rapid genetic drift, while the Bantu distributions are more even. Genetic distances computed from DRB1 allelic frequencies among 21 populations from North and sub-Saharan Africa were applied to a multidimensional scaling analysis. African populations genetic structure is significantly shaped by linguistic differentiation, as confirmed by an analysis of molecular variance. However, selective neutrality tests indicate that many African populations exhibit an excess of heterozygotes for DRB1, which is likely to explain the genetic similarity observed between some North African and Bantu populations. Overall, this study shows that natural selection must be taken into account when interpreting the patterns of HLA diversity, but that this effect is probably minor in relation to the stochastic events of human population differentiations. Adult Aged Central African Republic/ethnology Democratic Republic of the Congo/ethnology Female Gene Frequency MHC Class II Genes HLA-DP Antigens/genetics HLA-DQ Antigens/genetics HLA-DR Antigens/genetics Haplotypes Humans Linkage Disequilibrium Male Middle Aged Genetic Polymorphism Dewey 599.9 Dewey 590 44 Département de génétique et évolution 162 140 Département d'anthropologie et écologie 164 false 1056 Unité d'anthropologie Tissue antigens 58 4 eed89085-29c4-44af-b6ea-483cf70a80ba Article (Accepted version) Restricted article.pdf 207139 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de génétique et évolution Faculté des sciences / Section de biologie / Département d'anthropologie et écologie

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HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity	Tissue antigens			2001	671	2

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Renquin, Johan