Divergent Evolution among Teleost V1r Receptor Genes

Article Article scientifique Article Divergent Evolution among Teleost V1r Receptor Genes eng 2007 author Pfister Patrick Bernard Rudolf 502572 author Randall Jérôme 526241 author Montoya Burgos Juan Ignacio 47049 author Rodriguez Ivan 28183 e379 10.1371/journal.pone.0000379 1932-6203 http://dx.plos.org/10.1371/journal.pone.0000379 The survival of vertebrate species is dependent on the ability of individuals to adequately interact with each other, a function often mediated by the olfactory system. Diverse olfactory receptor repertoires are used by this system to recognize chemicals. Among these receptors, the V1rs, encoded by a very large gene family in most mammals, are able to detect pheromones. Teleosts, which also express V1r receptors, possess a very limited V1r repertoire. Here, taking advantage of the possibility to unequivocally identify V1r orthologs in teleosts, we analyzed the olfactory expression and evolutionary constraints of a pair of clustered fish V1r receptor genes, V1r1 and V1r2. Orthologs of the two genes were found in zebrafish, medaka, and threespine stickleback, but a single representative was observed in tetraodontidae species. Analysis of V1r1 and V1r2 sequences from 12 different euteleost species indicate different evolutionary rates between the two paralogous genes, leading to a highly conserved V1r2 gene and a V1r1 gene under more relaxed selective constraint. Moreover, positively-selected sites were detected in specific branches of the V1r1 clade. Our results suggest a conserved agonist specificity of the V1R2 receptor between euteleost species, its loss in the tetraodontidae lineage, and the acquisition of different chemosensory characteristics for the V1R1 receptor. Dewey 590 Dewey 616.8 44 Département de génétique et évolution 162 53 Département de neurosciences fondamentales 21A false PloS one 2 4 ba5f30a4-588f-4a19-a1d1-4102dcc451f2 Article (Published version) Public journal.pone.0000379.PDF 890051 application/pdf CC BY openAccess Faculté des sciences / Section de biologie / Département de génétique et évolution Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Divergent Evolution among Teleost V1r Receptor Genes	PloS one			2007	571	480

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Pfister, Patrick Bernard Rudolf