Two electrophysiological stages of spatial orienting towards fearful faces: early temporo-parietal activation preceding gain control in extrastriate visual cortex

Article Article scientifique Article Two electrophysiological stages of spatial orienting towards fearful faces: early temporo-parietal activation preceding gain control in extrastriate visual cortex eng 2005 author Pourtois Gilles 563434 author Thut Gregor 114551 author Grave De Peralta Menendez Rolando 500480 author Michel Christoph 91629 author Vuilleumier Patrik 0000-0002-8198-9214 134853 149-163 10.1016/j.neuroimage.2005.01.015 15862215 1053-8119 https://www.sciencedirect.com/science/article/pii/S1053811905000303 Visuo-spatial attention tends to be prioritized towards emotionally negative stimuli such as fearful faces, as opposed to neutral or positive stimuli. Using a covert orienting task, we previously showed that a lateral occipital P1 component, with extrastriate neural sources, was selectively enhanced to lateralized visual targets replacing a fearful face (fear-valid trial) than the same targets replacing a neutral face (fear-invalid trial), providing evidence for exogenous spatial orienting of attention towards threat cues. Here, we describe a new analysis of these data, using topographic evoked potentials mapping methods combined with a distributed source localization technique. We show that an early field topography (40-80 ms post-target onset) with a centro-parietal negativity and a left posterior parietal source distinguished fear-valid from fear-invalid trials, whereas a distinct activity with anterior cingulate sources was selectively evoked during fear-invalid trials. At the same latency, or later, no difference in field topography was found for valid compared to invalid trials with happy faces. The early parietal map preceded a modulation in amplitude of the field strength (approximately 130 ms), corresponding to the enhanced lateral occipital P1 during valid trials in the fear condition. Furthermore, this early topography at 40-80 ms was positively correlated with the subsequent amplitude modulation of P1 at 130-160 ms in the fear condition, suggesting a possible functional coupling between these two successive events. These data have important implications for models of spatial attention and interactions with emotion. They suggest two successive stages of neural activity during exogenous orienting of attention towards visual targets following fearful faces, including an early posterior parietal negativity, followed by gain control mechanisms enhancing visual responses in extrastriate occipital cortex. Adult Attention/physiology Brain Mapping Cues Electroencephalography Electrophysiology Emotions/physiology Evoked Potentials, Visual/physiology Facial Expression Fear/ psychology Female Humans Male Orientation/ physiology Parietal Lobe/ physiology Photic Stimulation Space Perception/ physiology Temporal Lobe/ physiology Visual Cortex/ physiology Dewey 616.8 Dewey 128.37 15 Centre interfacultaire en sciences affectives 0D8 false 1241 Affective sciences 118 Organisation et plasticité des réseaux neuronaux cérébraux 148 NeuroImage 26 1 bfe759e4-90b0-4438-b988-41dc0e36d992 Article Restricted file1.pdf 568107 application/pdf restrictedAccess Centres et instituts / Centre interfacultaire en sciences affectives

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Two electrophysiological stages of spatial orienting towards fearful faces: early temporo-parietal activation preceding gain control in extrastriate visual cortex	NeuroImage			2005	554	0

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Grave De Peralta Menendez, Rolando