Acquired and transient RBC CD55 deficiency (Inab phenotype) and anti-IFC

Article Article scientifique Revue de la littérature Acquired and transient RBC CD55 deficiency (Inab phenotype) and anti-IFC eng 2002-11 author Matthes Thomas 27368 author Tullen Emanuelle author Poole Joyce author Banks Jackie author Nagy Monika 514344 author Stelling Marie-José 24072 author Boehlen Françoise 33004 author Michel Martine 48415 author Beris Photis 26494 author Hustinx Hein author Crew Vanja author Daniels Geoff 1448-1457 10.1046/j.1537-2995.2002.00214.x 12421218 0041-1132 Background: Antigens of the Cromer blood group system reside on the glycoprotein CD55 (decay-accelerating factor). The Inab phenotype is the null phenotype of this system. So far, only five propositi have been described who exhibit this phenotype, and single-nucleotide substitutions in the CD55 gene have been found in three of them. This report describes the first example of a patient with an acquired and transient form of the Inab phenotype. Case report: A 54-year-old black patient was admitted to the hospital because of abdominal pain. Multiple splenic infarctions were visualized in the abdominal computerized tomography scan, and a prophylactic splenectomy was performed. The patient's serum reacted by an IAT with all donor RBCs tested. Results: Serologic analysis showed that the patient had the rare Inab phenotype and that his serum contained anti-IFC. Flow cytometry demonstrated the absence of CD55 on his RBCs, whereas lymphocytes, monocytes, granulocytes, and platelets expressed CD55, albeit at a weaker level than cells of common phenotypes. cDNA revealed no differences from the published sequences. Flow cytometry performed 12 months after splenectomy showed reappearance of the CD55 antigen; serologic tests performed after 17 months revealed that the anti-IFC had almost disappeared and that the RBCs were again agglutinated by various Cromer antibodies. Conclusion: A patient with an acquired and transient form of the Inab phenotype is described, in whom the CD55 deficiency is limited to the RBCs and is associated with splenic infarctions. Abdominal Pain / etiology Antibody Specificity Autoantibodies / biosynthesis Autoantibodies / blood Autoantibodies / immunology Blood Group Antigens / blood CD55 Antigens / blood CD59 Antigens / blood Cell Line, Transformed Cell Lineage Coombs Test Erythrocyte Membrane / immunology Hemoglobinuria, Paroxysmal / blood Humans Isoantibodies / blood Isoantibodies / immunology Kenya / ethnology Lymphocytes / immunology Male Middle Aged Myeloid Cells / immunology Phenotype Sickle Cell Trait / blood Sickle Cell Trait / complications Splenectomy Splenic Infarction / blood Splenic Infarction / immunology Splenic Infarction / surgery Thrombophilia / complications Dewey 616 56 Département de médecine 221 false 586 Analyses cellulaires et moléculaires des hémopathies malignes 929 323 BOEHLEN FRANCOISE 589 Transfusion 42 11 a3625dae-9421-4d55-a0e3-fc93a87016b4 Article (Published version) Restricted file.pdf 303299 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Acquired and transient RBC CD55 deficiency (Inab phenotype) and anti-IFC	Transfusion			2002	272	0

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Michel, Martine