Group B streptococcus in prosthetic hip and knee joint-associated infections

Article Article scientifique Article Group B streptococcus in prosthetic hip and knee joint-associated infections eng 2011 author Sendi Pedram 83120 author Christensson B author Uckay Ilker 134868 author Trampuz A author Achermann Yvonne 47000 author Boggian K author Svensson D author Widerström M author Zimmerli W 64-69 10.1016/j.jhin.2011.04.022 21764170 0195-6701 The incidence of invasive group B streptococcus (GBS) infections in non-pregnant adults is increasing. Little is known about GBS in periprosthetic joint infections (PJIs). We aimed to analyse the clinical presentation of GBS PJI and its treatment in association with the outcome. The characteristics of 36 GBS PJIs collected from 10 centres were investigated. In 34 episodes, follow-up examination of = 2 years was available, allowing treatment and outcome analysis. Most infections (75%) occurred = 3 months after implantation. Most patients (91%) had at least one comorbidity; 69% presented with acute symptoms and 83% with damaged periprosthetic soft tissue. In 20 of 34 episodes debridement and retention of implant was attempted, but in five of these the prosthesis was ultimately removed. Hence, in 19 (56%) episodes, the implant was removed, including 14 immediate removals. In four episodes the removal was permanent. Penicillin derivatives and clindamycin were the most common antimicrobials administered (68%). In 94% the infection was cured, and in 82% functional mobility preserved. Debridement with implant retention was successful if the duration of symptoms was short, the prosthesis stable, and the tissue damage minor (10/10 vs 3/10 episodes, P = 0.003). Surgery that complied with a published algorithm was associated with a favourable outcome (P = 0.049). Aged Anti-Bacterial Agents/administration & dosage Debridement Female Hip Joint/microbiology Humans Knee Joint/microbiology Male Osteoarthritis/epidemiology/microbiology/therapy Prosthesis Retention Prosthesis-Related Infections/epidemiology/microbiology/therapy Streptococcal Infections/epidemiology/microbiology/therapy Streptococcus agalactiae/isolation & purification Treatment Outcome Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 74 Chirurgie orthopédique et traumatologique 98 526 Résistance aux antibiotiques 866 19 Glycopeptide résistance 28 The Journal of hospital infection 79 1 151aa7bd-4f80-4394-9ed2-67f2d7945325 Article (Published version) Restricted 2011_sendl_j_hosp_infect.pdf 200714 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Group B streptococcus in prosthetic hip and knee joint-associated infections	The Journal of hospital infection			2011	612	0

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Achermann, Yvonne