Acceptability of an Electronic Patient-Reported Outcomes-Based Model of Care to Monitor Symptoms Related to Cancer Treatment with Immune Checkpoint Inhibitors : Results from the IePRO Randomized Controlled Trial

Article Article scientifique Article Acceptability of an Electronic Patient-Reported Outcomes-Based Model of Care to Monitor Symptoms Related to Cancer Treatment with Immune Checkpoint Inhibitors : Results from the IePRO Randomized Controlled Trial eng 2025-05-24 2025-08 author Lopes André Manuel da Silva Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Institute for Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne University Hospital, Lausanne, Switzerland. author Giacomini Stellio Haute École de Santé Vaud, Lausanne, Switzerland. author Ulahannan Ambily Institute for Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne University Hospital, Lausanne, Switzerland. author Darnac Celia Haute École de Santé Genève, Genève, Switzerland. author Bugeia Sébastien Department of Oncology, Geneva University Hospital, Geneva, Switzerland. 448150 author Gutknecht Garance Department of Oncology, Geneva University Hospital, Geneva, Switzerland. 449058 author Colomer-Lahiguera Sara Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Institute for Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne University Hospital, Lausanne, Switzerland. author Spurrier-Bernard Gilliosa Mélanome France, Teilhet, France. author Latifyan Sofiya Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland. author Addeo Alfredo Department of Oncology, Geneva University Hospital, Geneva, Switzerland. 912644 Département de médecine (DEMED) author Michielin Olivier 0000-0003-4926-6355 Department of Oncology, Geneva University Hospital, Geneva, Switzerland. 903944 Département de médecine (DEMED) author Eicher Manuela Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Institute for Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: manuela.eicher@chuv.ch. 151903 10.1016/j.soncn.2025.151903 40413059 0749-2081 https://www.sciencedirect.com/science/article/pii/S0749208125000968 Objectives: This study analyzed the acceptability of an electronic patient-reported outcomes measures-based model of care (IePRO MoC) and the usability of its complementary ePROM mobile app to monitor and manage symptoms related to immune checkpoint inhibitors. In this MoC, symptoms reported by patients treated at an outpatient clinic were reviewed by oncology triage nurses who provided symptom management interventions by telephone. Methods: As part of a larger intervention trial (ClinicalTrials.gov.NCT05530187) we conducted an abductive, semantic thematic analysis through semistructured interviews of patients participating in the intervention arm. Acceptability was deduced from Sekhon et al's (2017) Theoretical Framework of Acceptability completed with inductively generated themes. Usability analysis was guided by the mHealth App Usability Questionnaire's domains by Zhoul et al (2019). Results: A total of 17 interviews were performed. The IePRO MoC was reported to be an acceptable intervention. Patients expressed feeling safe and empowered due to continuous monitoring and timely support from nurses. Personalized support motivated patients to use the MoC throughout treatment. Some questioned the predefined response options of the app, and the standardized approach regarding notifications and monitoring requirements. Despite high app usability, some expressed discomfort from being frequently reminded of their illness and being confronted with questions about their sexuality and other intimate themes. Conclusions: The feedback loop between patients and nurses facilitated the acceptability of the IePRO MoC. The app's usability further facilitated adherence to the MoC. A more personalized approach regarding the frequency of assessments and the way symptoms are conveyed is recommended to decrease discomfort and support the implementation of similar MoCs in the future. Acceptability Care model Mobile application Patient-reported outcomes Symptom monitoring Usability Humans Neoplasms / drug therapy Patient Reported Outcome Measures Female Male Immune Checkpoint Inhibitors / adverse effects Immune Checkpoint Inhibitors / therapeutic use Middle Aged Aged Adult Mobile Applications Telemedicine Aged, 80 and over Dewey 616 56 Département de médecine 221 false 1432 Découverte de biomarqueurs numériques pour l'oncologie de précision 1059 Seminars in oncology nursing 41 4 ffb4a192-e869-4927-ae78-dcff3abdbcb3 Article (Published version) Public 1-s2.0-S0749208125000968-main.pdf 859477 application/pdf CC BY-4.0 3bdce248db5f40cae5d64a86f87df359bde1fecbe01e33b890cf9af9bb10d6eb openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Acceptability of an Electronic Patient-Reported Outcomes-Based Model of Care to Monitor Symptoms Related to Cancer Treatment with Immune Checkpoint Inhibitors : Results from the IePRO Randomized Controlled Trial	Seminars in oncology nursing			2025	9	78

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