Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Carcinomatosis in Colorectal Cancer Patients : A Systematic Review of the Evidence

Article Article scientifique Revue de la littérature Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Carcinomatosis in Colorectal Cancer Patients : A Systematic Review of the Evidence eng 2024-10-30 2024-10-30 author Sleiman Marwan Julien 0000-0001-5412-439X Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 971522 Marwan Sleiman author Jelip Annamaria Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 433729 author Buchs Nicolas Division of Digestive Surgery, Hôpital La Tour, 1217 Meyrin, Switzerland. author Toso Christian 0000-0003-1652-4522 Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 92271 Département de chirurgie (CHIRU) author Liot Emilie Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 867202 author Kossler Thibaud Division of Oncology, University Hospitals of Geneva, 1205 Geneva, Switzerland. 500516 Département de médecine (DEMED) author Meyer Jérémy 0000-0003-3381-9146 Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 583453 Département de chirurgie (CHIRU) author Meurette Guillaume Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 403298 Département de chirurgie (CHIRU) author Ris Frédéric 0000-0001-7421-6101 Division of Digestive Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland. 53083 Département de chirurgie (CHIRU) 3661 10.3390/cancers16213661 39518099 2072-6694 PMC11544814 https://www.mdpi.com/2072-6694/16/21/3661 Introduction: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) consists of the administration of aerosolized chemotherapy into the abdominal cavity of patients suffering from peritoneal carcinomatosis. Our aim was to review the evidence supporting PIPAC in patients with peritoneal carcinomatosis from colorectal cancer. Methods: A systematic review was performed in accordance with the 2020 PRISMA guideline. MEDLINE and CENTRAL were searched using combinations of terms including "Peritoneal carcinomatosis", "Peritoneal metastasis", "PIPAC", "Pressurized intraperitoneal aerosol chemotherapy" and "Colorectal cancer". Original studies, in English, including patients treated with PIPAC for colorectal peritoneal carcinomatosis, were considered eligible. Case reports, non-English or French language articles and secondary analyses were excluded. Results: A total of 385 articles were screened and 374 articles were excluded, leaving 11 publications for inclusion in the qualitative analysis. The included studies totalized 949 patients who received PIPAC for peritoneal carcinomatosis due to colorectal cancer. The median peritoneal carcinomatosis index (PCI) ranged from 10 to 31. In all studies, the complete PIPAC protocol was achieved with an average of two to three 3 PIPAC sessions per patient. Oxaliplatin (OX) was used as a chemotherapeutic agent in all studies and could be associated with intravenous 5-FU and leucovorin. Most post-operative adverse events were recorded as mild to moderate with no intraoperative complications. Only four studies reported a decrease in the average PCI score for 50% of the patients. Median overall survival ranged from 8 to 37.8 months. Quality of life indicators were stable between PIPAC-OX cycles with a small but not statistically significant trend of improvement of most functional scales. Conclusions: PIPAC for peritoneal carcinomatosis from colorectal origin is feasible, safe and tolerable. Its impact on survival outcomes or quality of life remains to be demonstrated by randomized trials. PIPAC Colorectal cancer EPIPAC Peritoneal carcinomatosis Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 1329 Chirurgie viscérale (HUG) 562 Transplantation et hépatologie 905 Cancers 16 21 3b0e9a30-22aa-4654-86b6-561d822701bf Article (Published version) Public Article_scientifique_from_crossref.pdf 545831 application/pdf CC BY-4.0 fff7bb4cbf0cfd2c8c0d5cd0355ff3e29aee66b77768cb29ef5655da8c661965 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Carcinomatosis in Colorectal Cancer Patients : A Systematic Review of the Evidence	Cancers			2024	90	1,072

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