Sodium stibogluconate (pentostan) overdose in a patient with acquired immunodeficiency syndrome

Article Article scientifique Article Sodium stibogluconate (pentostan) overdose in a patient with acquired immunodeficiency syndrome eng 1998 author Reymond Jane Madelaine 43296 author Desmeules Jules Alexandre 73542 714-716 10.1097/00007691-199812000-00023 9853993 0163-4356 A 32-year-old man with acquired immunodeficiency syndrome (AIDS) admitted to the hospital for treatment of visceral leishmaniasis was inadvertently given 10 times the prescribed first dose of sodium stibogluconate ([Sb] 6.5 g instead of 0.65 g). He experienced no immediate major toxicity during the first 48 hours, but a significant rise of pancreatic enzyme activities was observed (amylase at 10 times the upper limit of normal, lipase at 50 times the upper limit of normal) without clinical signs or indications on computed tomography (CT) of pancreatitis. The third day after the overdose, he developed appendicitis, which appeared coincidental; he recovered uneventfully from surgery. Most of the overdose of Sb was eliminated within the first few hours. Pharmacokinetics remained linear; the rapid, long elimination half-lives (2.7 hours and 54 hours, respectively) were similar to those in previously published results. The administration of a chelating agent, dimercaptosuccinic acid (DMSA), 72 hours after the Sb overdose did not modify the pharmacokinetics of the medication. Acquired Immunodeficiency Syndrome/complications Adult Amylases/blood/drug effects Antimony Sodium Gluconate/pharmacokinetics/poisoning Antiprotozoal Agents/poisoning Half-Life Humans Leishmaniasis, Visceral/drug therapy Lipase/blood/drug effects Male Medication Errors Succimer/pharmacology Time Factors Tomography Scanners, X-Ray Computed Dewey 617 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 Therapeutic drug monitoring 20 6 Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Sodium stibogluconate (pentostan) overdose in a patient with acquired immunodeficiency syndrome	Therapeutic drug monitoring			1998	461	0

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Reymond, Jane Madelaine