Time-of-day dependency of adoptive cell therapies

Article Article scientifique Revue de la littérature Time-of-day dependency of adoptive cell therapies eng 2025-07-16 2025-10 author Tellinga Constant Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland. 422991 Département de pathologie et immunologie (PATIM) author Friedli Roman Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland. 432448 Département de pathologie et immunologie (PATIM) author Simonetta Federico Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland; Division of Hematology, Department of Oncology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland; Translational Research Centre in Onco-Hematology (CRTOH), Geneva 1211, Switzerland; Geneva Centre for Inflammation Research (GCIR), Geneva 1211, Switzerland. 936876 Département de médecine (DEMED) author Scheiermann Christoph 0000-0002-9212-0995 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland; Translational Research Centre in Onco-Hematology (CRTOH), Geneva 1211, Switzerland; Geneva Centre for Inflammation Research (GCIR), Geneva 1211, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), Geneva 1211, Switzerland; Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany. Electronic address: christoph.scheiermann@unige.ch. 891044 Département de pathologie et immunologie (PATIM) 927-933 10.1016/j.trecan.2025.06.011 40670243 2405-8025 https://www.sciencedirect.com/science/article/pii/S2405803325001542 Adoptive cell therapies (ACTs), such as chimeric antigen receptor (CAR)-T cell therapy, have revolutionized cancer treatment, especially for hematological cancers. However, patient responses vary considerably. Emerging research reveals a striking influence of time of day (ToD) on ACT efficacy. Administering ACT during the early behavioral active phase enhances tumor control and reduces toxicity in preclinical models, an effect linked to the circadian clock. Latest clinical data also point to ToD effects in the cancer setting. In this opinion article we explore current insights and discuss the emerging underlying mechanisms. We propose that integrating ToD into clinical practice could represent a powerful yet easily implementable therapeutic regimen to improve efficacy and safety of ACT. CAR-T Adoptive cell therapy Chronotherapy Circadian Time of day Humans Immunotherapy, Adoptive / methods Immunotherapy, Adoptive / adverse effects Neoplasms / therapy Neoplasms / immunology Receptors, Chimeric Antigen / immunology Receptors, Chimeric Antigen / metabolism Animals Time Factors T-Lymphocytes / immunology T-Lymphocytes / transplantation Treatment Outcome Circadian Clocks / immunology Dewey 616.07 Dewey 616 Dewey 590 European Commission Regulation and relevance of circadian leukocyte dynamics for skin immune homeostasis 101001233 CIRCADYN EU H2020 Swiss National Science Foundation Generation of a circadian atlas of immune cells in barrier epithelial tissues 219256 CH Swiss National Science Foundation Defining the neural circuits that functionally link the brain with lymph nodes 10000652 CH 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 23 Institut de génétique et de génomique 0DH false 1259 L'influence du rôle du cycle circadien sur l'immunité 995 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 1426 Thérapie cellulaire et transplantation 1054 Trends in cancer 11 10 fef7f278-6b8b-41b1-8ba6-fcb7fa988052 Article (Published version) Public Tellinga_et_al_Trends_Cancer_2025.pdf 750613 application/pdf CC BY-4.0 54d7de1fdd4c84afb2fc21a1378a9c55e826f91bca82adffab0a196b793cefd0 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Centres et instituts / Institut de génétique et de génomique

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