Nanoparticles Dysregulate the Human Placental Secretome with Consequences on Angiogenesis and Vascularization

Article Article scientifique Article Nanoparticles Dysregulate the Human Placental Secretome with Consequences on Angiogenesis and Vascularization eng 2024-05-20 2024-07 author Dugershaw-Kurzer Battuja 0000-0002-7598-9357 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland.,Department of Health Sciences and Technology, ETH Zurich, Zurich, 8093, Switzerland. author Bossart Jonas 0000-0001-9004-3503 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland.,Department of Health Sciences and Technology, ETH Zurich, Zurich, 8093, Switzerland.,SIB, Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland. author Buljan Marija 0000-0003-3615-6691 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland.,SIB, Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland. author Hannig Yvette 0000-0001-8388-9201 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland. author Zehnder Sarah 0000-0003-0735-5747 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland. author Gupta Govind 0000-0003-4703-418X Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland. author Kissling Vera M 0000-0002-4524-9905 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland. author Nowak-Sliwinska Patrycja 0000-0002-8299-0444 Institute of Pharmaceutical Sciences of Western Switzerland, Geneva, 1211, Switzerland.,School of Pharmaceutical Sciences, University of Geneva, Geneva, 1205, Switzerland. 848409 Section des sciences pharmaceutiques (FARMA) author van Beijnum Judy R 0000-0003-4309-3713 Angiogenesis Laboratory, Department of Medical Oncology, UMC loacation Vrije Universiteit Amsterdam, Amsterdam, 1081, The Netherlands. author Griffioen Arjan W 0000-0002-8508-4754 Angiogenesis Laboratory, Department of Medical Oncology, UMC loacation Vrije Universiteit Amsterdam, Amsterdam, 1081, The Netherlands. author Masjosthusmann Stefan IUF-Leibniz Research Institute for Environmental Medicine, 40225, Duesseldorf, Germany. author Zühr Etta 0009-0006-3088-2683 IUF-Leibniz Research Institute for Environmental Medicine, 40225, Duesseldorf, Germany. author Fritsche Ellen 0000-0002-7454-679X IUF-Leibniz Research Institute for Environmental Medicine, 40225, Duesseldorf, Germany.,Medical Faculty, Heinrich Heine University, 40225, Duesseldorf, Germany.,DNTOX GmbH, 40223, Duesseldorf, Germany. 432131 author Hornung René Department of Gynaecology and Obstetrics, Cantonal Hospital St.Gallen (KSSG), St. Gallen, 9007, Switzerland. author Rduch Thomas 0000-0002-7486-5002 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland.,Department of Gynaecology and Obstetrics, Cantonal Hospital St.Gallen (KSSG), St. Gallen, 9007, Switzerland. author Buerki-Thurnherr Tina 0000-0003-3723-6562 Laboratory for Particles-Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, 9014, Switzerland. 2401060 10.1002/advs.202401060 38767187 2198-3844 PMC11267331 https://onlinelibrary.wiley.com/doi/10.1002/advs.202401060 Exposure to nanoparticles (NPs) in pregnancy is increasingly linked to adverse effects on embryo-fetal development and health later in life. However, the developmental toxicity mechanisms of NPs are largely unknown, in particular potential effects on the placental secretome, which orchestrates many developmental processes pivotal for pregnancy success. This study demonstrates extensive material- and pregnancy stage-specific deregulation of placental signaling from a single exposure of human placental explants to physiologically relevant concentrations of engineered (silica (SiO<sub>2</sub> ) and titanium dioxide (TiO<sub>2</sub> ) NPs) and environmental NPs (diesel exhaust particles, DEPs). This includes a multitude of secreted inflammatory, vascular, and endocrine placental factors as well as extracellular vesicle (EV)-associated proteins. Moreover, conditioned media (CM) from NP-exposed explants induce pronounced anti-angiogenic and anti-vasculogenic effects, while early neurodevelopmental processes are only marginally affected. These findings underscore the potential of metal oxide NPs and DEPs for widespread interference with the placental secretome and identify vascular morphogenesis as a sensitive outcome for the indirect developmental toxicity of different NPs. Overall, this work has profound implications for the future safety assessment of NPs for industrial, commercial, or medical applications in pregnancy, which should consider placenta-mediated toxicity by holistic secretomics approaches to ensure the development of safe nanotechnologies. Angiogenesis Developmental toxicity Nanoparticles Placenta Secretome Dewey 615 Swiss National Science Foundation Exploring indirect embryo-fetal risks of nanomaterials: Interference with inflammatory, vascular and endocrine signaling from human placental tissue 179337 CH Projects 31 Section des sciences pharmaceutiques 17 false 1325 Pharmacologie moléculaire Advanced science 11 28 e49596ba-b57d-40ed-907e-e6e7be941999 Article (Published version) Public Article_scientifique_from_unpaywall.pdf 9226436 application/pdf CC BY-4.0 a60d8e11239d3011ff33e3076d2671002784bf3f909f4c48bee608fa447b0745 openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Nanoparticles Dysregulate the Human Placental Secretome with Consequences on Angiogenesis and Vascularization	Advanced science			2024	34	193

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