Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMRO2

Article Article scientifique Article Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMRO2 eng 2025-10-10 2025 author Zhang Ke Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany. author Triphan Simon M F Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany. author Wielpütz Mark O Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.,Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. author Jende Johan Division of Radiology, German Cancer Research Center, Heidelberg, Germany. author Sleight Emilie CIBM Center for Biomedical Imaging, Geneva, Switzerland. 430650 author Ziener Christian Herbert Division of Radiology, German Cancer Research Center, Heidelberg, Germany. author Ladd Mark E Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany. author Schlemmer Heinz-Peter Division of Radiology, German Cancer Research Center, Heidelberg, Germany. author Kauczor Hans-Ulrich Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany. author Sedlaczek Oliver Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.,Division of Radiology, German Cancer Research Center, Heidelberg, Germany. author Kurz Félix Tobias 0000-0001-7616-7147 Division of Radiology, German Cancer Research Center, Heidelberg, Germany.,Division of Neuroradiology, Geneva University Hospitals, Geneva, Switzerland. 419472 1534844 10.3389/fneur.2025.1534844 41142155 1664-2295 PMC12549280 Rationale and objectives: Only a few studies examined the correlation between cerebrovascular reactivity (CVR) and other physiological parameters such as cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ). In this study, these baseline parameters were measured using 3D MRI with whole brain coverage for the investigation of global and regional correlation between each other to enhance understanding of brain function and improve tumor diagnosis. Materials and methods: All measurement were performed at 3 T. CVR was derived from a breath-holding task. Baseline CBF was measured by pseudo-continuous arterial spin labeling. Baseline OEF was measured with a gradient-echo sampling of spin-echo pulse sequence. T1 weighted anatomical image (T1W) was measured using MPRAGE sequence. CVR was calculated using customized written programs. CBF was quantified by using ASLtbx. For OEF analysis, a feedforward artificial neural network was used. CMRO2 was calculated based on smoothed and normalized CBF and OEF. General linear regression analysis was used to examine the relations between CVR and other parameters in five lobes of gray matter including frontal, parietal, temporal, occipital and insula lobes in individual healthy subjects. Spearman correlation was performed to check the regional correlations in an Automated Anatomical Labeling (AAL) atlas. Results: Fifteen healthy volunteers and five patients with brain tumors were included. In the healthy subjects, five lobes had a positive correlation between CBF and CVR (p  < 0.05). Similarly, in five lobes positive correlations between CMRO2 and CVR were found (p  < 0.05), as well as significant inter- and intra-subject correlations (p  < 0.001). However, there were no significant correlations between OEF and other parameters. Conclusion: Our findings demonstrate that CVR is strongly associated with CBF and CMRO₂ at both global and regional levels in healthy brains, but not with OEF. These results provide new insight into the complex interplay between vascular reactivity, perfusion, and metabolism and underscore the potential of combined CVR-CBF-CMRO2 imaging for assessing brain health and pathology. Cerebral blood flow Cerebral metabolic rate of oxygen Cerebrovascular reactivity Correlationship Oxygen extraction fraction Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false 1470 Laboratoire de neuroimagerie quantitative et computationnelle 1078 Frontiers in neurology 16 694cece1-6da9-406f-a708-ea953b1d1afb Article (Published version) Public Article_scientifique_from_europePmc.pdf 6149964 application/pdf CC BY-4.0 ab5bae69c580575f5111e872fe17304e930a86bd40498d6bbb818ed7780c9483 9e76095e-5612-4ffa-9ad8-34d6823376d2 Supplemental data Public image_1.tif 151826 image/tiff c7ca08a09465b97d64195d88e5da9662643dd09e906f8d79237dfcff8fd7e58b b80a2276-41ef-49a4-9b60-c3238bae54ce Supplemental data Public image_2.tif 4370466 image/tiff 38ad61b3e993140fa3f985bfb46c37ceeebab68c16a86b0f3a14e528b29b6c1b 4ffef25c-63ef-4a17-a356-b05aa64ed311 Supplemental data Public image_3.tif 3915284 image/tiff 7c14c9ed69b0757af2e531109a599946af83243ff1855efc5e3d34d065534e7b 39f65bcd-a56b-49c7-852e-e5ef86b4fe78 Supplemental data Public image_4.tif 4088302 image/tiff d874a4ca644545093df7929c6791c145e17aefffa11d96de7f2811d824c4a0f6 f0572a69-0df5-4cc7-b8cf-372e6fe25e7b Supplemental data Public image_5.tif 74084 image/tiff b37ec479b2bcc11dee808a1bda8b7370a5914d96d8c60c2d7ba26bcd8dfc72d0 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMRO₂	Frontiers in neurology			2025	3	6

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