An Update on Breakthrough Invasive Mold Infections

Article Article scientifique Revue de la littérature An Update on Breakthrough Invasive Mold Infections eng 2024-06-13 2024-08 author Portillo Tunon Vera Division of Infectious Diseases, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland. veraportillo@gmail.com.,Internal Medecine, Ensemble Hospitalier de la Côte, Hôpital de Moges, Chemin de la Crêt 2, Morges, Vaud, Switzerland. veraportillo@gmail.com. 430627 author Neofytos Dionysios 0000-0001-6970-2869 Division of Infectious Diseases, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland. dionysios.neofytos@hcuge.ch. 911674 Département de médecine (DEMED) 56 10.1007/s11046-024-00864-z 38869662 0301-486X PMC11176211 https://link.springer.com/10.1007/s11046-024-00864-z The incidence of breakthrough mold infections (bIMI) has been increasing, due to routine administration of broad-spectrum antifungal prophylaxis and an increasing pool of high-risk patient populations, with fungi more challenging to treat, resulting in a sustained high mortality, despite progress in diagnostic and therapeutic options. Pharmacokinetics of antifungal drugs, fungal, and host, including genetic, factors play a role in the emergence of bIMI. Suggested therapeutic approaches have included change of antifungal class treatment, with amphotericin-B products predominating as first-line empirical treatment and switching from one broad-spectrum azole to another remaining the most frequently used treatment modalities. Future perspectives include determining individual susceptibility to IMI to tailor prophylaxis and treatment strategies, improved diagnostic tests, and the introduction of new antifungal agents that may reduce morbidity and mortality caused by bIMI. Breakthrough fungal infections Breakthrough mold infections Posaconazole Dewey 616 56 Département de médecine 221 false Mycopathologia 189 4 9b0d9a8e-3db1-4e8b-b6ea-49a6bc5d0232 Article (Published version) Public Article_scientifique_from_crossref.pdf 437112 application/pdf CC BY-4.0 548c86b7d895d1637757bd818fd98db88a7f28b0caa1476c665dd55ba5ea9b21 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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An Update on Breakthrough Invasive Mold Infections	Mycopathologia			2024	8	77

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Portillo Tunon, Vera