Periodontitis and diabetes : a bidirectional link

Article Article scientifique Revue de la littérature Periodontitis and diabetes : a bidirectional link eng 2026-02-02 author Nguyen Thanh T author Bandeira Miguel 429301 CUMD - Clin. méd.dent.régénérative & parodontologie (CPAR) author Giannopoulou Catherine 23966 CUMD - Div. médecine dentaire régénérative & parodontologie - Communs (DPAR) author Zekeridou Alkisti 792319 CUMD - Clin. méd.dent.régénérative & parodontologie (CPAR) author Ryu Dongryeol author Gariani Karim 542849 Département de médecine (DEMED) 10.1007/s00592-026-02642-3 41627402 0940-5429 https://link.springer.com/article/10.1007/s00592-026-02642-3 Periodontitis is a chronic inflammatory disease affecting the tooth-supporting structures, and its closely linked to diabetes mellitus through a well-established bidirectional relationship. Diabetes exacerbates periodontal destruction via systemic inflammation, oxidative stress, and immune dysfunction, while periodontitis can impair glycemic control by increasing systemic inflammatory burden. The pathogenesis of periodontitis remains only partially understood, involving microbial dysbiosis, host immune responses, and metabolic disturbances. The 2018 classification system defines stages and grades based on disease severity and progression risk. Epidemiological data reveal a high global prevalence, particularly among individuals with type 2 diabetes. Studies have shown that periodontal therapy contributes to improved glycemic control and may reduce cardiovascular risk. Despite its clinical significance, periodontitis remains underdiagnosed in the context of diabetic care. Effective management requires integrated medical and dental collaboration, targeting both glycemic regulation and periodontal health. This dual approach offers mutual benefits for reducing complications and improving long-term outcomes in diabetic patients. In this review, we present the current knowledge on the relationship between diabetes and periodontitis, focusing on epidemiology, pathogenesis, and management. Cardiovascular Diabetes Oral health Oral inflammation Periodontitis Dewey 617.6 Dewey 616 206 Division de paradontologie 24P2 56 Département de médecine 221 false 360 Groupe Giannopoulou Catherine (médecine dentaire) 626 Acta diabetologica ec6f9a39-9b31-4974-8a19-1609eb4c511e Article (Published version) Public Periodontitis_and_diabetes__a_bidir.pdf 2514675 application/pdf CC BY-4.0 adeb89f67b1d7ffe92331172502b9659a3dce100216fa9095797bcb11e90ea8d openAccess Faculté de médecine / Section de médecine dentaire / Département de médecine dentaire préventive et de premier recours / Division de paradontologie Faculté de médecine / Section de médecine clinique / Département de médecine

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Periodontitis and diabetes : a bidirectional link	Acta diabetologica			2026	22	393

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Bandeira, Miguel