Clinical translation of FLASH radiotherapy : Why and how?

Article Article scientifique Revue de la littérature Clinical translation of FLASH radiotherapy : Why and how? eng 2019-06-25 2019-10 author Bourhis Jean Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Radiation Oncology Laboratory, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. Electronic address: jean.bourhis@chuv.ch. author Montay-Gruel Pierre Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Radiation Oncology Laboratory, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. author Gonçalves Jorge Patrik Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Radiation Oncology Laboratory, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Institute of Radiation Physics, Lausanne University Hospital Lausanne University, Switzerland. author Bailat Claude Institute of Radiation Physics, Lausanne University Hospital Lausanne University, Switzerland. author Petit Benoît Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Radiation Oncology Laboratory, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. 418880 Département de radiologie et informatique médicale (RADIO) author Ollivier Jonathan Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland; Radiation Oncology Laboratory, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. 423696 Département de radiologie et informatique médicale (RADIO) author Jeanneret-Sozzi Wendy Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. author Ozsahin Mahmut Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. author Bochud François Institute of Radiation Physics, Lausanne University Hospital Lausanne University, Switzerland. author Moeckli Raphaël Institute of Radiation Physics, Lausanne University Hospital Lausanne University, Switzerland. author Germond Jean-François Institute of Radiation Physics, Lausanne University Hospital Lausanne University, Switzerland. author Vozenin Marie-Catherine 0000-0002-2109-8073 Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland. 416827 Département de radiologie et informatique médicale (RADIO) 11-17 10.1016/j.radonc.2019.04.008 31253466 0167-8140 https://linkinghub.elsevier.com/retrieve/pii/S0167814019303603 Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical trial have recently shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. In the present review, we summarize the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters and the potential technologies needed for a successful clinical translation. Clinical trial Differential effect FLASH-radiotherapy Normal tissue protection Swiss National Science Foundation La balance entre quiescence et proliferation peut-elle expliquer l'effet differenciel exercé par la radiothérapie FLASH sur le cerveau sain par rapport au Glioblastome: role potentiel des voies c-kit/PI3K et Notch? 156892 CH Projects Swiss National Science Foundation FLASH, a novel radiotherapy modality: Understanding physical interaction and biological effect of FLASH radiotherapy on haematopoiesis and leukaemia 156924 CH Projects true 1429 Innovation en Radiobiologie appliquée à la Radiothérapie (LiRR) 1056 Radiotherapy and oncology 139 37bbaaba-cceb-4505-91fc-d3d26b6b0d71 Article (Published version) Restricted Bourhis19.pdf 672267 application/pdf 2c3ef7cdb3b5a2beb6a4ef21a2c5ae7fae010260cb10bd988d55021796361d1c restrictedAccess

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Clinical translation of FLASH radiotherapy : Why and how?	Radiotherapy and oncology			2019	78	0

Archive ouverte UNIGE

Ollivier, Jonathan