Influence of time-of-day of graft infusion on allogeneic hematopoietic stem cell transplantation outcomes : a validation cohort study

Article Article scientifique Article Influence of time-of-day of graft infusion on allogeneic hematopoietic stem cell transplantation outcomes : a validation cohort study eng 2025-12-25 2025-12-25 author Bernardi Chiara Division of Hematology, Geneva University Hospitals, Geneva, Switzerland chiara.bernardi@hug.ch federico.simonetta@unige.ch.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 956723 Département de médecine (DEMED) author Pradier Amandine Division of Hematology, Geneva University Hospitals, Geneva, Switzerland.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 660960 Département de médecine (DEMED) author Masouridi Levrat Stavroula Division of Hematology, Geneva University Hospitals, Geneva, Switzerland. 844685 Département de médecine (DEMED) author Morin Sarah Division of Hematology, Geneva University Hospitals, Geneva, Switzerland.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 935831 author Mamez Anne-Claire Division of Hematology, Geneva University Hospitals, Geneva, Switzerland. 918000 author Giannotti Federica Division of Hematology, Geneva University Hospitals, Geneva, Switzerland. 918560 author Hajj Younes Yara Division of Hematology, Geneva University Hospitals, Geneva, Switzerland.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 429355 Département de médecine (DEMED) author Wang Sisi Division of Hematology, Geneva University Hospitals, Geneva, Switzerland.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 966349 Département de médecine (DEMED) author Purwar Pragallabh Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 409746 Département de médecine (DEMED) author Tellinga Constant 0009-0005-5248-1840 Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 422991 Département de pathologie et immunologie (PATIM) author Villard Jean Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.,Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland.,Geneva Centre for Inflammation Research (GCIR), University of Geneva, Geneva, Switzerland. 29595 Département de médecine (DEMED) author Chalandon Yves 0000-0001-9341-8104 Division of Hematology, Geneva University Hospitals, Geneva, Switzerland.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 644957 Département de médecine (DEMED) author Scheiermann Christoph 0000-0002-9212-0995 Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.,Geneva Centre for Inflammation Research (GCIR), University of Geneva, Geneva, Switzerland.,Institute for Cardiovascular Physiology and Pathophysiology, LMU Hospital Walter Brendel Center of Experimental Medicine, Munich, Germany. 891044 Département de pathologie et immunologie (PATIM) author Simonetta Federico Division of Hematology, Geneva University Hospitals, Geneva, Switzerland chiara.bernardi@hug.ch federico.simonetta@unige.ch.,Translational Research Center for Oncohematology, Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.,Geneva Centre for Inflammation Research (GCIR), University of Geneva, Geneva, Switzerland. 936876 Département de médecine (DEMED) e013372 10.1136/jitc-2025-013372 41448834 2051-1426 PMC12742167 https://jitc.bmj.com/content/13/12/e013372 The biological clock plays a central role in hematopoiesis and immune regulation, making circadian rhythms an increasingly important factor in immunotherapies and cellular therapies such as allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous work by Hou <i>et al</i> suggested that afternoon graft infusions were associated with a higher risk of acute graft-versus-host disease and worse survival, highlighting a potential role for infusion timing in shaping transplant outcomes.To further investigate this, we performed a retrospective analysis of 368 patients who underwent allo-HSCT at Geneva University Hospitals between 2015 and 2024. Observing that infusion timing patterns at our center differed from those reported by Hou <i>et al</i> , we applied a data-driven approach using receiver operating characteristic analysis, which identified 11:17 as the optimal cut-off for overall survival.Stratification using this threshold revealed that patients receiving grafts before 11:00 had significantly improved 2-year overall survival and lower non-relapse mortality compared with those infused later in the day, with no differences in relapse or engraftment rates.These findings suggest that infusion timing may be an important, under-recognized factor influencing allo-HSCT outcomes. Prospective clinical trials are needed to confirm these observations and explore their applicability across different clinical contexts. Graft versus host disease - GVHD Hematologic Malignancies Infusion Transplant Humans Hematopoietic Stem Cell Transplantation / methods Hematopoietic Stem Cell Transplantation / adverse effects Male Female Middle Aged Adult Retrospective Studies Transplantation, Homologous / methods Graft vs Host Disease / etiology Time Factors Treatment Outcome Young Adult Adolescent Aged Dewey 610 Dewey 616 Dewey 616.07 56 Département de médecine 221 4f7589ed-e44d-4850-a4d8-b0c1eccdfe48 Centre de recherche translationnelle en onco-hématologie 209 137 Département de pathologie et immunologie 21F false 1216 Leucémie et transplantation allogénique de cellules souches hématopoïétiques 982 1426 Thérapie cellulaire et transplantation 1054 1259 L'influence du rôle du cycle circadien sur l'immunité 995 298 Immunologie de transplantation, immunogénétique et thérapie cellulaire 561 Journal for immunotherapy of cancer 13 12 a9ff6817-15ff-4c00-b11b-cdd0f4535e7d Article (Published version) Public Article_scientifique_from_europePmc.pdf 409934 application/pdf CC BY-NC-4.0 3b6ec201b0334f4ed1960e1dd8b2bc0e9329f5d37ae7765d5a184346ff1ae887 84895b2e-7b1c-43d6-9bb0-911204f69b72 Supplemental data Public inline-supplementary-material-1.pdf 105290 application/pdf f96cfe8e2a30e963135abb37e2706c5c416c1701e2b18d3010ce6ed8cddde738 e21037fe-3521-4c05-911c-92ea006a83a0 Supplemental data Public inline-supplementary-material-2.pdf 55795 application/pdf 2099394c8b6da9a6726297978b92a5b585a6d4318ca107c4dd93c2940638ead0 7ef6168a-1bb0-40eb-89e9-8f5b7f2480f1 Supplemental data Public inline-supplementary-material-3.pdf 75426 application/pdf ca8765732742337e4e0c1628db82b9029e4ef12568ad3be262481dc5f7f09af5 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Centre de recherche translationnelle en onco-hématologie Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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