Signalomics for molecular tumor boards and precision oncology of breast and gynecological cancers

Article Article scientifique Revue de la littérature Signalomics for molecular tumor boards and precision oncology of breast and gynecological cancers eng 2025-06-09 author Denisenko Tatiana V Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina Str., Moscow, 117997, Russia. author Ivanova Anna Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina Str., Moscow, 117997, Russia. 418704 author Koval Alexey 0000-0002-8920-4426 Translational Research Centre in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211, Geneva, Switzerland. 910996 Département de physiologie cellulaire et métabolisme (PHYME) author Silachev Denis Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina Str., Moscow, 117997, Russia.,Translational Research Centre in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211, Geneva, Switzerland.,Department of Functional Biochemistry of Biopolymers, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia. 935136 Département de physiologie cellulaire et métabolisme (PHYME) author Jia Lee College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, 350108, China. author Sukhikh Gennadiy T Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina Str., Moscow, 117997, Russia. author Katanaev Vladimir 0000-0002-7909-5617 Translational Research Centre in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211, Geneva, Switzerland. vkatanaev@hbku.edu.qa.,Translational Oncology Research Center, Qatar Biomedical Research Institute (QBRI), College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, PO Box 34110, Doha, Qatar. vkatanaev@hbku.edu.qa. 910192 Département de physiologie cellulaire et métabolisme (PHYME) 10.1038/s44320-025-00125-1 40490498 1744-4292 https://www.embopress.org/doi/full/10.1038/s44320-025-00125-1 Precision oncology led to the establishment and widespread application of molecular tumor boards (MTBs)-multidisciplinary units combining molecular and clinical assessment of individual cancer cases for swift selection of personalized treatments. Whole-exome or gene panel sequencing, combined with transcriptomic, immunohistochemical, and other molecular analyses, often permits dissection of molecular drivers of a tumor and identification of its potential targetable vulnerabilities, instructing clinical oncologists on sometimes unconventional treatment options. However, cancer drivers are often unleashed mutation-independently, especially in breast and gynecological cancers, and deleterious mutations are not always pathogenic. To complement the MTB arsenal, we chart here the molecular toolset we call Signalomics that permits fast and robust assessment of a panel of oncogenic signaling pathways in fresh tumor samples. Using transcriptional reporters introduced in primary tumor cells, this approach identifies the pathways overactivated in a given tumor and validates their sensitivity to targeted therapies, providing actionable insights for personalized treatment strategies. Integration of Signalomics into MTB workflows bridges the gap between molecular profiling and functional pathway analysis, refining clinical treatment decisions and advancing precision oncology. Breast and Gynecological Cancers Molecular Tumor Board Oncogenic Signaling Pathways Precision Oncology Signalomics Dewey 612 134 Département de physiologie cellulaire et métabolisme 21C false 1264 Voies de signalisation oncogéniques 998 Molecular systems biology fb9b9d0a-305c-4853-9f07-a6caa793be81 Article (Published version) Public Mol_Syst_Biol_2025.pdf 2397904 application/pdf CC BY-4.0 199211ebcaf04fc2a18b5b27f99ce2b0c1e0c667e105b3fc7e0b14e642a787b8 openAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

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Signalomics for molecular tumor boards and precision oncology of breast and gynecological cancers	Molecular systems biology			2025	70	41

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