Concomitant cystic fibrosis and NSAID-exacerbated respiratory disease

Article Article scientifique Rapport de cas Concomitant cystic fibrosis and NSAID-exacerbated respiratory disease eng 2025-05-01 2025-08-01 author Le Bon Serge Department of Otorhinolaryngology, Rhinology-Olfactology Unit, Service of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland. 417731 author Plojoux Jérôme Pierre Olivier Department of Respiratory Medicine, Geneva University Hospitals, Geneva, Switzerland. 503040 author Coattrenec Yann Department of Immunology and Allergology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. 635051 author Landis Basile Nicolas Department of Otorhinolaryngology, Rhinology-Olfactology Unit, Service of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland. 133537 Département des neurosciences cliniques (OTONO) 505-506 10.4193/Rhin25.132 40407713 0300-0729 https://www.rhinologyjournal.com/Abstract.php?id=3296 Chronic rhinosinusitis (CRS) with nasal polyps occurs in 6-57% of individuals with cystic fibrosis (CF). According to the EPOS 2020 guidelines, CF-related CRS is classified as secondary diffuse, non-type-2 CRS. In contrast, most nasal polyposis in the general population is associated with primary, type-2 CRS. This educationally-oriented classification system facilitates the categorization of CRS in distinct groups. However, it may suggest that each type of CRS is caused by a single underlying mechanism, potentially leading clinicians to overlook that, in reality, multiple factors can drive CRS development. The incidence of CRS stemming from multiple etiologies remains currently underexplored. We report an illustrative case of a CF patient with concomitant NSAID-Exacerbated Respiratory Disease (NERD), necessitating two distinct targeted therapies to achieve effective symptomatic relief. Dewey 616.8 Dewey 616 56 Département de médecine 221 61 Département des neurosciences cliniques 226 false Rhinology 64 4 43579ede-d1ac-478b-b93c-2643e359ab1b Article (Published version) Restricted manuscript_3296.pdf 482458 application/pdf db1e5cde1ab40c4587327f2bcdb44f6e59c1bbc9091338a69f38fe07a4db3ed7 restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Concomitant cystic fibrosis and NSAID-exacerbated respiratory disease	Rhinology			2025	6	0

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Le Bon, Serge