Pain induced by platelet-rich plasma injections : reality or myth and short-medium term efficiency in a large retrospective cohort

Article Article scientifique Article Pain induced by platelet-rich plasma injections : reality or myth and short-medium term efficiency in a large retrospective cohort eng 2025-11-08 2026-01 author Garaud Sarah Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: sarah.garaud@gmail.com. 413370 author Hamard Marion Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: marion.hamard@hcuge.ch. 633651 author Gorican Karel Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: gorican.karel@gmail.com. 902461 author Bouredoucen Hicham Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: hicham.bouredoucen@hcuge.ch. 419059 author Knuchel Charles Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: charles.knuchel@hcuge.ch. 527027 author Ferreira Branco David Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: david.branco@hcuge.ch. 406916 author Poletti Pierre-Alexandre Alois Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: pierre-alexandre.poletti@hcuge.ch. 34563 Département de radiologie et informatique médicale (RADIO) author Boudabbous Sana Division of Radiology, Department of Imaging, Geneva University Hospitals, Geneva, Switzerland. Electronic address: sana.boudabbous@hcuge.ch. 800627 Département de radiologie et informatique médicale (RADIO) 107166 10.1016/j.crad.2025.107166 41371172 0009-9260 https://www.sciencedirect.com/science/article/pii/S000992602500371X Aim: The aim of our study was to assess pain during PRP injections and to evaluate correlations with pathology, anatomical location and needle size. The second goal was to evaluate the improvement in pain in the short and medium term. Materials and methods: Overall, 389 (195 males and 194 females) consecutive patients addressed for PRP injections were prospectively included. Pain during infiltration was evaluated using a visual analogue scale (VAS). Correlations with pathology, anatomical location and needle size were analyzed. Pain response was assessed in the short term, (10-15 days), and in the medium term (3 months). Results: A total of 215 patients suffered from tendinopathy and 174 from osteoarthritis. Median age was 47.7 years old for tendinopathy and 46.03 years old for osteoarthritis. During injections, a significant difference was noticed between the groups (Mann-Whitney: p=0.0124). But no significant influence of the needle size or the anatomical location on recorded pain during injection (p=0.222). Improvement of short-term or medium-term pain values compared with the day of injection was not significant (p=0.3992, p=0.1202 respectively). Conclusion: Our study showed that PRP injections were associated with a higher level of pain in patients with tendinopathy than in those with arthritis, regardless of anatomical location or needle size. No improvement in pain was noticed in the short and medium term. Adult Aged Female Humans Injections / adverse effects Male Middle Aged Osteoarthritis / therapy Pain Measurement Pain / etiology Platelet-Rich Plasma Retrospective Studies Tendinopathy / therapy Dewey 616.0757 62 Département de radiologie et informatique médicale 227 false 469 Radiologie des urgences 800 Clinical radiology 92 c87729ab-5bbb-4c40-aded-deff64e699bf Article (Published version) Restricted PIIS000992602500371X.pdf 2093162 application/pdf 6e4f783a40ee7ef221bd288dc1899ec54455235e6780550dc5df59ba6fe1ee7f restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Pain induced by platelet-rich plasma injections : reality or myth and short-medium term efficiency in a large retrospective cohort	Clinical radiology			2026	6	0

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Garaud, Sarah