Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH

Article Article scientifique Article Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH eng 2005 author Diaz del Consuelo Isabel author Falson Françoise author Guy Richard H. 109747 author Desjacques Yves 41310 1525-1529 10.1007/s11095-005-6020-y 0724-8741 Purpose. To validate pig esophageal epithelium as a model for the permeability barrier of the buccal mucosa, the transport of fentanyl across the two tissues was compared in vivo. Methods. The epithelia were separated by immersing the excised mucosae into an isotonic saline solution at 60–65°C. Fentanyl was delivered as the citrate salt at a concentration of 1 or 2 mg/mL buffered at one of four pH values (between 6.0 and 7.4). Results. Across both barriers, drug transport increased proportionally with concentration as expected. However, drug flux was not linearly related to the unionized fraction of the drug; indeed, fentanyl delivery was significant even when 98.5% of the drug was in the ionized form. Conclusions. Buccal and esophageal fluxes were very similar under all conditions suggesting that the esophageal epithelium is a representative tool for buccal transport studies in vitro. Buccal epithelium Diffusion Esophageal epithelium Fentanyl Permeability Transport Dewey 615 31 Section des sciences pharmaceutiques 17 false Pharmaceutical research 22 9 49b67730-3933-458e-b115-16232a6cb2d5 Article (Published version) Public CONSUELO_PR_20051529.pdf 333557 application/pdf OA NATIONAL 370f52a1e73374b5ed77461babd5835bb99af8344a9920a409686dc51ebad53b openAccess Faculté des sciences / Section des sciences pharmaceutiques

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Transport of fentanyl through pig buccal and esophageal epithelia in vitro: influence of concentration and vehicle pH	Pharmaceutical research			2005	68	120

Archive ouverte UNIGE

Desjacques, Yves