Menstrual management using hormonal medications in adolescents and young adults with developmental disability : a systematic review and a meta-analysis

Article Article scientifique Revue de la littérature Menstrual management using hormonal medications in adolescents and young adults with developmental disability : a systematic review and a meta-analysis eng 2025-06-27 2025-12-31 author Moussaoui Dehlia 0000-0002-6987-4916 Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 642525 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Laqua Judith Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 406210 author Crofts Victoria 0000-0002-4488-2012 Division of Gynecology, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 646382 author Piguet Camille Marie 0000-0003-4317-0918 Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 541240 Département de psychiatrie (PSYAT) Camille Marie Nemitz author Heritier Barras Anne-Chantal Programme Handicap, Medical and Quality Directorate, Geneva University Hospitals, Geneva, Switzerland. 27107 author Merglen Arnaud Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 104541 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Yaron Michal Division of Gynecology, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 668428 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 2521804 10.1080/01443615.2025.2521804 40576248 0144-3615 https://www.tandfonline.com/doi/full/10.1080/01443615.2025.2521804 Background: Adolescents with developmental disability (DD) may experience similar menstrual disorders as their peers, as well as unique challenges associated with their underlying conditions. They have access to the same hormonal medications as the general population, but little is known about the effects of menstrual management in adolescents with DD. The aim of this study was to assess the efficacy, satisfaction with, side effects and complications of hormonal medications that are used for menstrual management in adolescents and young adults with DD. Methods: A systematic review was performed in Medline, Embase, Cochrane library and PsycNet, using keywords related to menstrual management, hormonal medications, adolescents and disability. Meta-analyses of proportions were conducted for outcomes that could be combined across studies. Results: Of the 2088 articles identified, 20 studies were included. The total number of participants was 3317 and varied significantly across studies (from 14 to 1560 individuals). Menstrual management was associated with a reduction in bleeding and high rates of amenorrhoea. We found that 45.4% (95% CI, 32.1-59%) of levonorgestrel-intrauterine device users experienced amenorrhoea. Satisfaction was high with all methods and correlated with the reduction in bleeding. Breakthrough bleeding was the most common side effect and the primary reason for ceasing or switching medication. No case of venous thromboembolism was reported. Conclusions: Menstrual management was associated with improvement in menstrual symptoms and high levels of satisfaction in adolescents with DD. Side effects and complication rates were low in this population. This should support the use of menstrual management in adolescents with DD, who deserve similar access to menstrual health care as their peers. Adolescents Disability Dysmenorrhoea Heavy menstrual bleeding Menstrual management Dewey 616.89 Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 60 Département de psychiatrie 225 false 1391 Régulation émotionnelle chez les adolescents et jeunes adultes 1042 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 Journal of obstetrics and gynaecology 45 1 69d044c4-67b4-4656-916d-373e3710b7c8 Article (Published version) Public Menstrual management using hormonal1.pdf 2529403 application/pdf CC BY-4.0 d95a699116c2edae7319e9140bbd16c387f22c10a199ded499fb045fcf502e98 e3fab014-6c37-4c8e-83b0-621afb6f26b7 Supplemental data Public ijog_a_2521804_sm4982.docx 48182 application/vnd.openxmlformats-officedocument.wordprocessingml.document 43fb52a2a6c99e0750875886ccb4547c816a51ab25b6b33753ae7d55c774bf7f 2757968c-dc6f-4008-88cf-5a758a626463 Supplemental data Public ijog_a_2521804_sm4983.pdf 88165 application/pdf 2896440e58c2d31469bd048b5f9dc24f33ae779769c02be74ac0c202418fa7da openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Menstrual management using hormonal medications in adolescents and young adults with developmental disability : a systematic review and a meta-analysis	Journal of obstetrics and gynaecology			2025	45	42

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Laqua, Judith