The contribution of cognitive reserve in explaining the dual-task walking performance in iNPH patients : comparison with other cognitive, functional, and socio-demographic variables

Article Article scientifique Article The contribution of cognitive reserve in explaining the dual-task walking performance in iNPH patients : comparison with other cognitive, functional, and socio-demographic variables eng 2024-09-11 2024-09-11 author Piche Elodie Université Côte d'Azur, LAMHESS, Nice, France. piche.e@chu-nice.fr.,Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Clinique Gériatrique du Cerveau et du Mouvement, Nice, France. piche.e@chu-nice.fr. 405099 author Armand Stéphane 0000-0001-9144-4982 Laboratory of Kinesiology, University Geneva Hospitals and University of Geneva, Geneva, Switzerland. stephane.armand@hug.ch. 636265 Département de chirurgie (CHIRU) author Allali Gilles Leenaards Memory Center, Lausanne University Hospitals and University of Lausanne, Lausanne, Switzerland. 507314 Département des neurosciences cliniques (OTONO) author Assal Frédéric Division of Neurology, Department of Clinical Neurosciences, University Geneva Hospitals, Geneva, Switzerland. 527005 Département des neurosciences cliniques (OTONO) 190 10.1007/s40520-024-02829-0 39259457 1594-0667 PMC11390896 https://link.springer.com/10.1007/s40520-024-02829-0 Background : Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent neurological disorder, but its diagnosis remains challenging. Dual-task (DT) walking performance is a reliable indicator of iNPH but less is known about the role of cognitive reserve (CR) in predicting DT walking performance. Aims : The objective of this study was to evaluate the contribution of CR on DT walking in healthy controls (HC) and in iNPH patients (iNPH-P). Methods : 68 iNPH-P (77.2 +/- 6.7 years old) and 28 HC (74.5 +/- 5.7 years old) were evaluated on their single-task walking ( Vsimple ) and on 4 DT walking (walking and counting or counting backwards, naming animals, naming words beginning with the letter P) ( Vcount , VcountB , Vanimals and Vletter respectively). The contribution of CR on the different DT walking speeds was compared between HC and iNPH-P. In iNPH-P, the contribution of CR on the walking speeds was compared with regard to other cognitive, functional, and socio-demographic variables. Results : Simple linear regression demonstrated a moderate influence of CR on single and DT walking speed in iNPH-P (β > 0.3, p < .001) but not in HC where the relation was not significant. In iNPH-P, results showed that CR played a major role in explaining each of the single and DT walking speeds with NPH-scale. Conclusion : As CR could be improved through the life cycle, these results support the idea of developing and supporting physical activity programs that will enrich social, physical, and cognitive resources to protect against age-related functional decline, especially in iNPH-P patients where the age-related deficits are greater. Cognitive reserve Dual-task walking Idiopathic normal pressure hydrocephalus Dewey 616.8 Dewey 617 Swiss National Science Foundation Reversible dementia: towards a network biomarker 173153 CH Projects 61 Département des neurosciences cliniques 226 57 Département de chirurgie 222 false 900 Laboratoire de cinésiologie 943 928 Neuropsychologie et neurologie comportementale 951 Aging Clinical and Experimental Research 36 1 9adce2c8-1e48-416b-b686-35d3fc91734f Article (Published version) Public Article_scientifique_from_crossref.pdf 1071616 application/pdf CC BY-4.0 f013d1d833f74acf92114adcf45a1a443733bbff5bded71a6e5c87ce70f676be openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de chirurgie

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The contribution of cognitive reserve in explaining the dual-task walking performance in iNPH patients : comparison with other cognitive, functional, and socio-demographic variables	Aging Clinical and Experimental Research			2024	68	144

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