Plasticity of human resilience mechanisms

Article Article scientifique Article Plasticity of human resilience mechanisms eng 2025-01-08 2025-01-10 author Leone Giovanni 0000-0003-2622-2843 Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.,Laboratory of Behavioural Neurology and Imaging of Cognition, Department of Neuroscience, Campus Biotech, University of Geneva, Geneva, Switzerland.,Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. 403310 Département de neurosciences fondamentales (NEUFO) author Casanave Hannah Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author Postel Charlotte Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author Fraisse Florence Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author Vallée Thomas 0000-0003-0060-355X Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author de La Sayette Vincent 0000-0003-0663-092X Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author Dayan Jacques 0000-0002-2304-1783 Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.,Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Centre Hospitalier Guillaume Régnier, Université Rennes 1, 35700 Rennes, France. author Peschanski Denis 0000-0002-8124-4116 Université Paris I Panthéon Sorbonne, HESAM Université, EHESS, CNRS, UMR8209, Paris, France. author Eustache Francis 0000-0003-4460-8686 Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. author Gagnepain Pierre 0000-0003-4949-9829 Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France. eadq8336 10.1126/sciadv.adq8336 39772669 2375-2548 PMC11708882 https://www.science.org/doi/10.1126/sciadv.adq8336 The hippocampus's vulnerability to trauma-induced stress can lead to pathophysiological disturbances that precipitate the development of posttraumatic stress disorder (PTSD). The mechanisms of resilience that foster remission and mitigate the adverse effects of stress remain unknown. We analyzed the evolution of hippocampal morphology between 2016/2017 and 2018/2019, as well as the memory control mechanisms crucial for trauma resilience. Participants were individuals exposed to the 2015 Paris terrorist attacks (N = 100), including chronic (N = 34) and remitted (N = 19) PTSD, and nonexposed (N = 72). We found that normalization of inhibitory control processes, which regulate the resurgence of intrusive memories in the hippocampus, not only predicted PTSD remission but also preceded a reduction in traumatic memories. Improvement in control mechanisms was associated with the interruption of stress-induced atrophy in a hippocampal region that includes the dentate gyrus. Human resilience to trauma is characterized by the plasticity of memory control circuits, which interacts with hippocampal neuroplasticity. PTSD Memory Memory control Hippocampus Resilience Dewey 128.37 Dewey 616.8 53 Département de neurosciences fondamentales 21A 15 Centre interfacultaire en sciences affectives 0D8 false 428 Mécanismes cérébraux du comportement et des fonctions cognitives 701 https://zenodo.org/records/14215568 Science advances 11 2 c9eb652f-228c-4016-8c4e-efa1587ae264 Article (Published version) Public sciadv.adq8336.pdf 1142240 application/pdf CC BY-NC-4.0 046d1252e04274a8c52c0d6708a15a4efce830bfb12382059b167e335bffee26 00677762-a254-4d98-83f9-faf3c3ce6737 Supplemental data Public sciadv.adq8336_sm.pdf 478041 application/pdf b2cf3d0bf9a0bfb08a8ee019043c0798c8103fc25631e305e170f851b7ae1a3c openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Centres et instituts / Centre interfacultaire en sciences affectives

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