Ni-Catalyzed Kumada–Corriu Cross-Coupling Reactions of Tertiary Grignard Reagents and Bromostyrenes

Article Article scientifique Article Ni-Catalyzed Kumada–Corriu Cross-Coupling Reactions of Tertiary Grignard Reagents and Bromostyrenes eng 2024-07-09 2024-07-19 author Li Kaidi 0009-0003-2570-352X Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland. 937694 author Zu Bing Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland. 403309 author Mazet Clement 0000-0002-2385-280X Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland. 667534 Département de chimie organique (CHIOR) 6047-6052 10.1021/acs.orglett.4c02185 38981082 1523-7052 https://pubs.acs.org/doi/10.1021/acs.orglett.4c02185 The development of protocols for the construction of congested quaternary centers is highly sought-after. Herein, we report a method for the cross-coupling of C(sp<sup>3</sup> ) tertiary Grignard reagents with C(sp<sup>2</sup> ) styrenyl bromides using readily available nickel precatalysts. We identified conditions that afford the products in practical yield for several combinations of electrophiles and nucleophiles, including sensitive α-magnesiated Grignard reagents. Dependent upon the nature of their substituents, regiodivergency was observed when α-vinyl bromides were employed. Dewey 540 Swiss National Science Foundation Increasing molecular complexity by selective catalysis 188490 CH Projects 36 Département de chimie organique 141 false 763 Groupe Mazet Organic letters 26 28 01d70d35-7ef5-44ec-ac04-8a06c6a6c782 Article (Published version) Restricted li-et-al-2024-ni-catalyzed-kumada-c.pdf 2913176 application/pdf a5a6bc391ed2454ee43d2d05a84c462633769608bb2003aacb356c7c465b0837 Vignette Public ol4c02185_0007.png 41526 image/png restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

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Ni-Catalyzed Kumada–Corriu Cross-Coupling Reactions of Tertiary Grignard Reagents and Bromostyrenes	Organic letters			2024	22	0

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