Imaging spectrum of Bing-Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström's macroglobulinemia?

Article Article scientifique Article Imaging spectrum of Bing-Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström's macroglobulinemia? eng 2018-06-19 2019-01 author Fitsiori Aikaterini 0000-0002-4540-1428 From the 2nd Radiology Department, University Hospital of Strasbourg, Avenue Molière 1, 67098, Strasbourg, France. Aikaterini.Fitsiori@hcuge.ch.,Division of Neuroradiology, Department of Imaging and Medical Information Sciences, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. Aikaterini.Fitsiori@hcuge.ch. 919174 author Fornecker Luc-Matthieu Haematology Department, University Hospital of Strasbourg, Strasbourg, France. author Simon Laurence Haematology Department, University Hospital of Strasbourg, Strasbourg, France. author Karentzos Alexandros Department of Visceral Surgery, Geneva University Hospitals, Geneva, Switzerland. 402457 author Galanaud Damien Department of Diagnostic and Functional Neuroradiology, Pitié-Salpêtrière Hospital of Paris, Paris, France. author Outteryck Olivier Neurology Department, University Hospital of Lille, Lille, France. author Vermersch Patrick Neurology Department, University Hospital of Lille, Lille, France. author Pruvo Jean-Pierre Radiology Department, University Hospital of Lille, Lille, France. author Gerardin Emmanuel Radiology Department, University Hospital of Rouen, Rouen, France. author Lebrun-Frenay Christine Neurology Department, University Hospital of Nice, Nice, France. author Lafitte Francois Radiology Department, Rothschild Foundation in Paris, Paris, France. author Cottier Jean-Philippe Radiology Department, University Hospital of Tours, Tours, France. author Clerc Christine Neurology Department, Montbéliard Hospital, Belfort, France. author de Seze Jerome Neurology Department, University Hospital of Strasbourg, Strasbourg, France. author Dietemann Jean-Louis From the 2nd Radiology Department, University Hospital of Strasbourg, Avenue Molière 1, 67098, Strasbourg, France. author Kremer Stephane From the 2nd Radiology Department, University Hospital of Strasbourg, Avenue Molière 1, 67098, Strasbourg, France. 102-114 10.1007/s00330-018-5543-7 29922935 0938-7994 https://link.springer.com/article/10.1007/s00330-018-5543-7 Objectives: Bing-Neel syndrome (BNS) is a rare neurological complication of Waldenström's macroglobulinemia. The aim of this study is to describe the spectrum of radiological manifestations of this syndrome and their prevalence in order to facilitate its early diagnosis. Methods: Twenty-four patients with BNS were diagnosed between 1994 and 2016 in eight centres in France. We retrospectively examined the medical records of these patients as well as the corresponding literature, focusing on imaging studies. Recorded data were statistically analysed and radiological findings described. Results: The mean age of our patients was 62.4 years (35-80 years). The vast majority of patients were men, with a male to female ratio of 9:1. Findings included parenchymal or meningeal involvement or both. The most common finding was leptomeningeal infiltration, either intracranial or spinal, with a prevalence reaching 70.8%. Dural involvement was present in 37.5% of patients. In 41.7% (10/24) of patients, there was parenchymal involvement with a higher prevalence of brain comparing to medullar involvement (33.3% and 23.1% respectively). High T2 signal of the parenchyma was identified in 41.7% of patients and high signal in diffusion was evident in 25% of them. Intraorbital or periorbital involvement was also detected in four cases. A proposition regarding the appropriate imaging protocol completed our study. Conclusion: BNS's diagnosis remains challenging. Central nervous system MRI findings in the setting of known or suspected Waldenström's macroglobulinemia appear to be highly suggestive of BNS and appropriate imaging protocols should be implemented for their depiction. Key points: • Diagnosis of Bing-Neel syndrome (BNS) remains challenging and recent expert recommendations include MRI in the diagnostic criteria for the syndrome. • The most common radiological manifestations of BNS are leptomeningeal/dural infiltration or parenchymal involvement of brain or spinal cord, but many atypical forms may exist with various presentations. • Appropriate imaging protocol for BNS should include enhanced MRI studies of both brain and spine. Central nervous system Lymphocytes Magnetic resonance imaging Meninges Adult Aged Aged, 80 and over Brain / diagnostic imaging Female France / epidemiology Humans Magnetic Resonance Imaging / methods Male Middle Aged Neurodegenerative Diseases / diagnosis Neurodegenerative Diseases / etiology Prevalence Reproducibility of Results Retrospective Studies Syndrome Waldenstrom Macroglobulinemia / complications Waldenstrom Macroglobulinemia / diagnosis Waldenstrom Macroglobulinemia / epidemiology Dewey 616.0757 Dewey 617 62 Département de radiologie et informatique médicale 227 57 Département de chirurgie 222 false 1329 Chirurgie viscérale (HUG) European radiology 29 1 4d47c03b-1be5-44a5-a482-b55078caa984 Article (Published version) Restricted s00330-018-5543-7.pdf 2956239 application/pdf 1736acf1ea4365ff53d718ac73928a4ca3d355adaea8965fd823d3b5644bfa36 restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de chirurgie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Imaging spectrum of Bing-Neel syndrome: how can a radiologist recognise this rare neurological complication of Waldenström's macroglobulinemia?	European radiology			2019	149	0

Archive ouverte UNIGE

Karentzos, Alexandros