State-of-the-science of human papillomavirus vaccination in women with human immunodeficiency virus : summary of a scientific workshop

Article Article scientifique Revue de la littérature State-of-the-science of human papillomavirus vaccination in women with human immunodeficiency virus : summary of a scientific workshop eng 2023-10 author Schuind Anne E. author Rees Helen author Schiller John author Mugo Nelly author Dull Peter author Barnabas Ruanne author Clifford Gary M. author Liu Gui author Madhi Shabir A. author Morse Rebecca 402379 author Moscicki Anna-Barbara author Palefsky Joel M. author Plotkin Stanley author Sierra Mónica S. author Slifka Mark K. author Vorsters Alex author Kreimer Aimée R. author Didierlaurent Arnaud 0000-0002-4736-9003 934659 Département de pathologie et immunologie (PATIM) 102331 10.1016/j.pmedr.2023.102331 37576844 2211-3355 PMC10413150 https://linkinghub.elsevier.com/retrieve/pii/S221133552300222X The burden of cervical cancer is disproportionately distributed globally, with the vast majority of cases occurring in low- and middle-income countries. Women with human immunodeficiency virus (HIV) (WWH) are at increased risk of human papillomavirus (HPV) infection and cervical cancer as compared to HIV-negative individuals. HPV vaccination remains a priority in regions with a high burden of cervical cancer and high HIV prevalence. With HPV vaccines becoming more accessible, optimal use beyond the initial World Health Organization-recommended target population of 9 to 14-year-old girls is an important question. In March 2022, a group of experts in epidemiology, immunology, and vaccinology convened to discuss the state-of-the-science of HPV vaccination in WWH. This report summarizes the proceedings: review of HIV epidemiology and its intersection with cervical cancer burden, immunology, HPV vaccination including reduced-dose schedules and experience with other vaccines in people with HIV (PWH), HPV vaccination strategies and knowledge gaps, and outstanding research questions. Studies of HPV vaccine effectiveness among WWH, including duration of protection, are limited. Until data from ongoing research is available, the current recommendation for WWH remains for a multi-dose HPV vaccination regimen. A focus of the discussion included the potential impact of HIV acquisition following HPV vaccination. With no data currently existing for HPV vaccines and limited information from non-HPV vaccines, this question requires further research. Implementation research on optimal HPV vaccine delivery approaches for WWH and other priority populations is also urgently needed. Epidemiology HPV vaccine Human papillomavirus (HPV) Immunization Immunology Prevention Vaccination strategies Human immunodeficiency virus (HIV) Women with HIV (WWH) Dewey 616.07 137 Département de pathologie et immunologie 21F false 1337 Laboratoire d'immunologie vaccinale humaine 1025 Preventive medicine reports 35 7f8faea0-5d98-43d0-89ac-099686c55d00 Article (Published version) Public 1-s2.0-S221133552300222X-main.pdf 3034622 application/pdf CC BY-4.0 386f15092e9741010bf02a14114eca002e1718e6d0f903f8ea87b25e4274f971 d7200096-60d0-4c40-bd71-f96a91a721db Supplemental data Public 1-s2.0-S221133552300222X-mmc1.docx 147441 application/vnd.openxmlformats-officedocument.wordprocessingml.document 6faaaf925425a71a3c4098f6415d8714033207a4d0aacaa3ebefde20b4aef2d6 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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State-of-the-science of human papillomavirus vaccination in women with human immunodeficiency virus : summary of a scientific workshop	Preventive medicine reports			2023	74	27

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Morse, Rebecca