Investigating the Interplay : Periodontal Disease and Type 1 Diabetes Mellitus-A Comprehensive Review of Clinical Studies

Article Article scientifique Revue de la littérature Investigating the Interplay : Periodontal Disease and Type 1 Diabetes Mellitus-A Comprehensive Review of Clinical Studies eng 2024-07-02 author Vlachou Stefania Division of Regenerative Dental Medicine and Periodontology, University Clinics of Dental Medicine, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland. 400588 CUMD - Clin. méd.dent.régénérative & parodontologie (CPAR) author Loumé Alexandre Division of Regenerative Dental Medicine and Periodontology, University Clinics of Dental Medicine, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland. 946898 CUMD - Clin. méd.dent.régénérative & parodontologie (CPAR) author Giannopoulou Catherine 0000-0001-7079-617X Division of Regenerative Dental Medicine and Periodontology, University Clinics of Dental Medicine, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland. 23966 CUMD - Div. médecine dentaire régénérative & parodontologie - Communs (DPAR) author Papathanasiou Evangelos 0000-0002-6425-4777 Department of Periodontology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA. author Zekeridou Alkisti Division of Regenerative Dental Medicine and Periodontology, University Clinics of Dental Medicine, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland. 792319 CUMD - Clin. méd.dent.régénérative & parodontologie (CPAR) 7299 10.3390/ijms25137299 39000406 1422-0067 PMC11242877 https://www.mdpi.com/1422-0067/25/13/7299 Diabetes mellitus (DM) poses a significant challenge to global health, with its prevalence projected to rise dramatically by 2045. This narrative review explores the bidirectional relationship between periodontitis (PD) and type 1 diabetes mellitus (T1DM), focusing on cellular and molecular mechanisms derived from the interplay between oral microbiota and the host immune response. A comprehensive search of studies published between 2008 and 2023 was conducted to elucidate the association between these two diseases. Preclinical and clinical evidence suggests a bidirectional relationship, with individuals with T1DM exhibiting heightened susceptibility to periodontitis, and vice versa. The review includes recent findings from human clinical studies, revealing variations in oral microbiota composition in T1DM patients, including increases in certain pathogenic species such asPorphyromonas gingivalis,Prevotella intermedia, andAggregatibacter actinomycetemcomitans, along with shifts in microbial diversity and abundance. Molecular mechanisms underlying this association involve oxidative stress and dysregulated host immune responses, mediated by inflammatory cytokines such as IL-6, IL-8, and MMPs. Furthermore, disruptions in bone turnover markers, such as RANKL and OPG, contribute to periodontal complications in T1DM patients. While preventive measures to manage periodontal complications in T1DM patients may improve overall health outcomes, further research is needed to understand the intricate interactions between oral microbiota, host response, periodontal disease, and systemic health in this population. Cellular mechanisms Diabetes mellitus Host immune response Molecular mechanisms Oral microbiota Oxidative stress Periodontal disease Periodontitis Type 1 diabetes mellitus Humans Diabetes Mellitus, Type 1 / microbiology Diabetes Mellitus, Type 1 / complications Microbiota Periodontal Diseases / microbiology Periodontitis / microbiology Periodontitis / complications Periodontitis / immunology Dewey 617.6 206 Division de paradontologie 24P2 false 360 Groupe Giannopoulou Catherine (médecine dentaire) 626 International journal of molecular sciences 25 13 a32c4663-9889-4737-9e17-da43f0465730 Article (Published version) Public Article_scientifique_from_europePmc.pdf 741529 application/pdf CC BY-4.0 6cd31b14ec894e9297f3e40f3fbe07d1d71f01d99a9e3b9a2a91317279423453 openAccess Faculté de médecine / Section de médecine dentaire / Département de médecine dentaire préventive et de premier recours / Division de paradontologie

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Investigating the Interplay : Periodontal Disease and Type 1 Diabetes Mellitus-A Comprehensive Review of Clinical Studies	International journal of molecular sciences			2024	96	643

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Vlachou, Stefania