Oncocytic adrenocortical neoplasm with concomitant papillary thyroid cancer

Article Article scientifique Article Oncocytic adrenocortical neoplasm with concomitant papillary thyroid cancer eng 2017 author Podetta Michèle 815523 author Pusztaszeri Marc 640736 author Toso Christian 0000-0003-1652-4522 92271 author Procopiou Michel 39024 author Triponez Frédéric 28673 author Sadowski Veuthey Mercedes Samira Doris 514552 384 10.3389/fendo.2017.00384 29403439 1664-2392 Adrenal oncocytoma (AO) is an extremely rare adrenocortical neoplasm and little is known about its malignant potential, secretory properties, and hereditary origin. We present the case of a benign AO with concomitant incidentally found papillary thyroid cancer (PTC) and review similar cases in the literature. Immunohistochemistry and next-generation sequencing (NGS) were performed. A 66-year-old women was incidentally found to have a large, androgen-secreting right adrenal mass.18F-Fluorodeoxyglucose positron emission tomography showed intense uptake (SUVmax88.7) of this mass and found a hypermetabolic right thyroid mass. Open adrenalectomy was performed for this highly suspicious adrenal mass. Histopathology revealed benign AO that was BRAFV600Enegative, with low Ki-67, and no somatic mutation found on NGS. Thyroidectomy revealed invasive, BRAFV600E-positive PTC. At 6 months follow-up, androgen levels returned to normal, and no recurrence was seen on imaging. To our knowledge, this is the first report of an androgen-secreting AO with concomitant PTC. Possibly the simultaneous discovery of two independent neoplasms was observed. In conclusion, this case highlights that care should be given to exclude concomitant neoplasms. Long-term and regular imaging with biochemical follow-up is warranted, since the outcome and clinical behavior of AO remains uncertain. Adrenal oncocytoma Concomitant neoplasia Functional adrenal neoplasm Hereditary cancer syndrome Papillary thyroid cancer Dewey 617 57 Département de chirurgie 222 false 902 Cancer du poumon et mésothéliome pleural malin 944 79 Chirurgie viscérale 104 1329 Chirurgie viscérale (HUG) 562 Transplantation et hépatologie 905 Frontiers in Endocrinology 8 311197f5-c3d3-4328-bbaf-31941960d847 Article (Published version) Public fendo-08-00384.pdf 2152351 application/pdf CC BY openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Oncocytic adrenocortical neoplasm with concomitant papillary thyroid cancer	Frontiers in Endocrinology			2017	666	251

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Procopiou, Michel