The apelinergic system in pregnancy

Article Article scientifique Revue de la littérature The apelinergic system in pregnancy eng 2023-04-28 2023-04-28 author Pecheux Océane 990496 author Correia Ana 0000-0001-5353-9665 38676 author Cohen Marie-Benoîte 0000-0003-4621-5464 135615 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Martinez De Tejada Weber Begona 0000-0001-5737-3586 590919 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) 8014 10.3390/ijms24098014 37175743 1422-0067 PMC10178735 https://www.mdpi.com/1422-0067/24/9/8014 <p>The apelinergic system is a highly conserved pleiotropic system. It comprises the apelin receptor apelin peptide jejunum (APJ) and its two peptide ligands, Elabela/Toddler (ELA) and apelin, which have different spatiotemporal localizations. This system has been implicated in the regulation of the adipoinsular axis, in cardiovascular and central nervous systems, in carcinogenesis, and in pregnancy in humans. During pregnancy, the apelinergic system is essential for embryo cardiogenesis and vasculogenesis and for placental development and function. It may also play a role in the initiation of labor. The apelinergic system seems to be involved in the development of placenta-related pregnancy complications, such as preeclampsia (PE) and intrauterine growth restriction, but an improvement in PE-like symptoms and birth weight has been described in murine models after the exogenous administration of apelin or ELA. Although the expression of ELA, apelin, and APJ is altered in human PE placenta, data related to their circulating levels are inconsistent. This article reviews current knowledge about the roles of the apelinergic system in pregnancy and its pathophysiological roles in placenta-related complications in pregnancy. We also discuss the challenges in translating the actors of the apelinergic system into a marker or target for therapeutic interventions in obstetrics.</p> APJ Elabela Apelin Placenta Preeclampsia Pregnancy Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 584 Laboratoire de biologie des tumeurs gynécologiques et du développement 927 213 Martinez De Tejada Begona 272 International journal of molecular sciences 24 9 03cccfef-24e3-4db9-aa1c-f12d39248bb5 Article (Published version) Public Article-scientifique-from-crossref.pdf 1458545 application/pdf CC BY-4.0 fd09f3aedd10abedd130d3f11de2dbd5c4f121594cd646dec7b1f3b1ce5d930f openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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The apelinergic system in pregnancy	International journal of molecular sciences			2023	111	466

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Correia, Ana