Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

Article Article scientifique Article Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis eng 2020 author Cloesmeijer Michael E author van Esdonk Michiel J author Lynn Anne M author Smits Anne Claudine Catherine 36515 author Tibboel Dick author Daali Youssef 46042 author Olkkola Klaus T author Allegaert Karel author Mian Paola 10.1111/bcp.14547 32901947 0306-5251 Ketorolac is a nonsteroidal anti-inflammatory racemic drug with analgesic effects only attributed to its S-enantiomer. The aim of this study is to quantify enantiomer-specific maturational pharmacokinetics (PK) of ketorolac and investigate if the contribution of both enantiomers to the total ketorolac concentration remains equal between infants and adults or if a change in target racemic concentration should be considered when applied to infants. Adults Analgesia Ketorolac Paediatrics Population pharmacokinetics Dewey 617 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 1280 Pharmaco-omiques et médecine de précision 1003 British Journal of Clinical Pharmacology e23c4a3e-1993-4abd-9a53-1cb1bbd536cd Article (Published version) Public bcp.14547.pdf 3254791 application/pdf CC BY-NC openAccess Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis	British Journal of Clinical Pharmacology			2020	237	224

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Smits, Anne Claudine Catherine