Haematopoietic stem cells and mesenchymal stem cells as tools for present and future cellular therapies

Article Article scientifique Revue de la littérature Haematopoietic stem cells and mesenchymal stem cells as tools for present and future cellular therapies eng 2006 author Kindler Vincent Lucien 30815 author Suva Domizio 590318 author Soulas Caroline 542853 author Chapuis Bernard Pierre 32297 333-337 10.4414/smw.2006.11039 16826633 0036-7672 http://www.smw.ch/docs/archive200x/2006/21/smw-11039.html Postnatal stem cells are present in many adult tissues, and are thought to ensure homoeostasis by replacing functionally declining cells by newly differentiated ones. Postnatal stem cells used as such or after in vitro manipulation hold out strong hopes for reconstructive therapies. For instance, the grafting of native haematopoietic stem cells (HSC) restores haematopoiesis in genetically deficient individuals or in lethally conditioned leukaemic patients, and systemic injection of in vitro amplified mesenchymal stem cells (MSC) induces recovery of bone growth in patients with osteogenesis imperfecta. Moreover, cells differentiated in vitro from postnatal stem cells exhibiting a specific function can also be used for cell therapy. Myeloid dendritic cells (DC) derived from cultures of HSC may induce tumour-specific cytotoxic T lymphocytes to eradicate the tumour via antigen recognition. In addition, long-lived MSC has been engineered to secrete specific proteins coded by a transgene and used as a source of therapeutic molecules in vivo. All these approaches require large quantities of cells that cannot be obtained (with the exception of HSC) directly from the donor. In vitro procedures allowing the production of therapeutic cells from postnatal stem cells are needed and are at present under development. Below we discuss the rationale and methods currently available for generation of therapeutic cells derived from haematopoietic and mesenchymal stem cells. Animals Antigen-Presenting Cells/cytology Cell Differentiation Cell Transplantation/trends Cells, Cultured Child Dendritic Cells/immunology Forecasting Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells/cytology Humans Leukemia/therapy Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells/cytology Mice Osteogenesis Imperfecta/therapy Papio Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 74 Chirurgie orthopédique et traumatologique 98 585 Immunité innée non leucocytaire 928 Schweizerische medizinische Wochenschrift 136 21-22 6ceed2ca-879f-4d72-b3bb-995613c66ea3 Article (Published version) Public smw-11039.pdf 1472374 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Haematopoietic stem cells and mesenchymal stem cells as tools for present and future cellular therapies	Schweizerische medizinische Wochenschrift			2006	637	271

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Chapuis, Bernard Pierre