Severe but reversible encephalopathy associated with cefepime

Article Article scientifique Article Severe but reversible encephalopathy associated with cefepime eng 2000 author Jallon Pierre-Marie 22338 author Fankhauser-Noetzli Laurence 651837 author Du Pasquier Renaud Alfred Robert 37491 author Coeytaux Alessandra Cécile Maria 28786 author Picard Fabienne 123049 author Hefft Stefan Martin 28783 author Assal Frédéric 527005 383-386 10.1016/S0987-7053(00)00234-3 11191931 1388-2457 In this study, a report has been made of 19 cases of severe encephalopathy in patients with renal impairment who were treated during the last three years for various infections with cefepime, a new parenteral cephalosporin antibiotic. All patients (aged 57 to 91 years) presented a prolonged confusional state associated with diffuse rhythmic non-reactive triphasic sharp waves on the EEG. All the electroclinical symptomatology disappeared within 24-48 hours after discontinuation of drug administration. A clear relation was found between encephalopathy and cefepime intake. These observations underline the fact that the cefepime dosage should be reduced in renally impaired patients. Aged Aged, 80 and over Bacterial Infections/complications/drug therapy Cephalosporins/adverse effects/therapeutic use Confusion/chemically induced Creatinine/blood/urine Electroencephalography Female Hallucinations/chemically induced Humans Kidney Diseases/complications Male Middle Aged Myoclonus/chemically induced Dewey 616.8 61 Département des neurosciences cliniques 226 false 928 Neuropsychologie et neurologie comportementale 951 Clinical neurophysiology 30 6 6d911f95-2928-43c9-a96e-e26966857f24 Article (Published version) Restricted Jallon_et_al_CN_2000.pdf 243624 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Severe but reversible encephalopathy associated with cefepime	Clinical neurophysiology			2000	640	0

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Hefft, Stefan Martin