Successful pregnancy and delivery after simultaneous islet-kidney transplantation

Article Article scientifique Article Successful pregnancy and delivery after simultaneous islet-kidney transplantation eng 2018 author Assalino Michela 791834 author Podetta Michèle 815523 author Mischler Sandrine 91656 author Francini Katyuska 28164 author Pernin Nadine 547983 author Randin Jean-Pierre author Bosco Domenico 23285 author Andres Axel 105988 author Berney Thierry 63319 10.1111/ajt.14884 29673064 1600-6135 Allogeneic islet of Langerhans transplantation is a recognized beta-cell replacement therapy for patients affected by type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition associated with an increased risk of adverse outcomes for pregnant women and fetuses We report the case of a 29 year-old woman with type 1 diabetes mellitus, who underwent successful allogeneic islet transplantation with simultaneous kidney transplantation. She achieved durable insulin independence after two islet infusions. Pregnancy was desired and planned 2 years after last islet infusion. Multidisciplinary monitoring of pregnancy was carried out and immunosuppressive regimen was adapted. Euglycemia was maintained throughout pregnancy without the need for exogenous insulin. After an uneventful pregnancy, she delivered on term an otherwise healthy male child with imperforate anus that was immediately surgically corrected. In conclusion, allogeneic islet transplantation is a suitable treatment for women of childbearing age with complicated type 1 diabetes mellitus, allowing physiologic glycemic control during pregnancy with a low risk of graft loss. This target can only be achieved by a tight multidisciplinary follow-up, including immunosuppressive therapy adaptation and adequate diabetes and obstetrical monitoring. This article is protected by copyright. All rights reserved. Dewey 617 57 Département de chirurgie 222 false 357 La transplantation d'îlots de Langerhans 623 American Journal of Transplantation 297c6c2e-002a-4070-809d-3b47538cd853 Article (Accepted version) Public Assalino_et_al-2018-American_Journal_of_Transplantation.pdf 407995 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Successful pregnancy and delivery after simultaneous islet-kidney transplantation	American Journal of Transplantation			2018	532	262

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Francini, Katyuska