Isolation and Characterization of a Cyclic Hydroxamic Acid from a Pollen Extract, Which Inhibits Cancerous Cell Growth in Vitro

Article Article scientifique Article Isolation and Characterization of a Cyclic Hydroxamic Acid from a Pollen Extract, Which Inhibits Cancerous Cell Growth in Vitro eng 1995 author Zhang Xin 27420 author Habib Fouad K. author Ross Margaret author Burger Ulrich 25497 author Lewenstein Ari author Rose Keith 21876 author Jaton Jean-Claude 25363 735-738 10.1021/jm00004a019 0022-2623 https://pubs.acs.org/doi/abs/10.1021/jm00004a019 One fraction, designated FV-7, in the water soluble ingredient of the pollen extract Cernilton was found to be inhibitory to the growth of a prostate cancer cell line. Characterization of FV-7 by high-resolution mass spectrometry and nuclear magnetic resonance identified the fraction as hydroxamic acid, 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA). To confirm this further, we synthesized an authentic sample of DIBOA and found subsequently that the synthetic DIBOA was structurally indistinguishable from FV-7. Furthermore, in a separate experiment we compared the in vitro effects of FV-7 and DIBOA on the growth of a prostate cancer cell line and found that in both cases the effect was inhibitory and that the inhibition curves obtained for both compounds were virtually identical. Dewey 540 Swiss National Science Foundation 31-33658-92 CH 36 Département de chimie organique 141 false Journal of Medicinal Chemistry 38 4 f49a8f97-edc7-47cc-a4c5-52fbe88f21f3 Article (Published version) Restricted jm00004a019.pdf 460941 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Isolation and Characterization of a Cyclic Hydroxamic Acid from a Pollen Extract, Which Inhibits Cancerous Cell Growth in Vitro	Journal of Medicinal Chemistry			1995	402	1

Archive ouverte UNIGE

Zhang, Xin