Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release

Article Article scientifique Article Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release eng 2009 author Butoescu Nicoleta Paula 630313 author Jordan Olivier 0000-0003-3752-2198 133859 author Burdet Pierre 26269 author Stadelmann Pierre author Petri-Fink Alke author Hofmann Heinrich author Doelker Eric 25151 529-538 10.1016/j.ejpb.2009.03.003 19303928 0939-6411 Compared with traditional drug solutions or suspensions, polymeric microparticles represent a valuable means to achieve controlled and prolonged drug delivery into joints, but still suffer from the drawback of limited retention duration in the articular cavity. In this study, our aim was to prepare and characterize magnetic biodegradable microparticles containing dexamethasone acetate (DXM) for intra-articular administration. The superparamagnetic properties, which result from the encapsulation of superparamagnetic iron oxide nanoparticles (SPIONs), allow for microparticle retention with an external magnetic field, thus possibly reducing their clearance from the joint. Two molecular weights of poly(lactic-co-glycolic acid) (PLGA) were used, 12 and 19 kDa. The prepared batches were similar in size (around 10 microm), inner morphology, surface morphology, charge (neutral) and superparamagnetic behaviour. The SPION distribution in the microparticles assessed by TEM indicates a homogeneous distribution and the absence of aggregation, an important factor for preserving superparamagnetic properties. DXM release profiles were shown to be quite similar in vitro (ca. 6 days) and in vivo, using a mouse dorsal air pouch model (ca. 5 days). Dewey 615 31 Section des sciences pharmaceutiques 17 false European journal of pharmaceutics and biopharmaceutics 72 3 4fc310e4-4648-407d-add4-8acc6a641db9 Article (Published version) Restricted ButoescuN_2009a_EJPB_DXM-containing biodegradable superparamagnetic microparticles for i-a administration.pdf 944112 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release	European journal of pharmaceutics and biopharmaceutics			2009	658	0

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Burdet, Pierre