Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Article Article scientifique Article Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report eng 2011 author Antonarakis Stylianos 22813 author Fokstuen Siv 133715 author Engel Eric 25399 author Dermitzakis Emmanouil 542683 author Bottani Armand 513397 author Dahoun Sophie 22913 author Morris Michael Andréw 24090 author Mostafavi Maryam 740172 841-847 10.1097/GIM.0b013e318217477f 21555946 1098-3600 Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3, 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. Consanguinity DNA Copy Number Variations Disease/genetics Female Genetic Research Humans Male Marriage Quantitative Trait, Heritable Dewey 576.5 Autre Jeantet 135 Département de médecine génétique et développement 21D false 196 Pathologie Moléculaire de la Trisomie 21 et le Génome Humain 248 551 Population Genomics and Genetics of Complex Traits 892 Genetics in medicine 13 9 ec008dc2-a6b5-4863-90e0-7c9d95ea0b62 Article (Published version) Restricted pmid21555946.pdf 738715 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report	Genetics in medicine			2011	671	2

Archive ouverte UNIGE

Engel, Eric