Electrotonic Propagation of Kinin-Induced, Endothelium-Dependent Hyperpolarizations in Pig Coronary Smooth Muscles

Article Article scientifique Article Electrotonic Propagation of Kinin-Induced, Endothelium-Dependent Hyperpolarizations in Pig Coronary Smooth Muscles eng 1996 author Koller Catherine 24487 author Schaad Olivier 0000-0003-1576-783X 23118 author Beny Jean-Louis 26368 380-385 10.1159/000159166 8862143 1018-1172 https://www.karger.com/Article/FullText/159166 The kinins, substance P and bradykinin, cause endothelium-dependent hyperpolarizations in smooth muscles of the pig coronary artery. We tested whether the propagation, in the media, of these hyperpolarizations is passive or whether the hyperpolarizations are regenerated in the smooth muscle cells. The space constants measured in response to the kinin endothelium-dependent stimulations were compared to those obtained by electrical field stimulation. The space constant is 2.6 ± 0.2 mm (n = 13) measured for substance P and 2.2 ± 0.2 mm (n = 12) for bradykinin. The space constants established by electrical field stimulation-induced hyperpolarization are 3 ± 0.2 mm (n = 7) for strips with intact endothelium and 2.7 ± 0.3 mm (n = 7) for strips with removed endothelium. These results show that the space constants obtained for the kinin stimulations are not larger than those caused by electrical field stimulation. This suggests that the kinin-induced hyperpolarizations propagate, in the media, in a passive, electronic manner, therefore the hypothesis of regenerated kinin hyperpolarizations is unlikely. Vascular smooth muscle Electrophysiology Cell-to-cell communication Kinins Endothelium-derived hyperpolarization Dewey 590 44 Département de génétique et évolution 162 false Journal of vascular research 33 5 782db9bf-9896-4468-9482-f0dc2a1e0ad6 Article (Published version) Restricted Pacicca_JVR_199633380.pdf 3676525 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de génétique et évolution

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Electrotonic Propagation of Kinin-Induced, Endothelium-Dependent Hyperpolarizations in Pig Coronary Smooth Muscles	Journal of vascular research			1996	241	0

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Koller, Catherine