Factors Influencing the Entrapment of a Water Soluble Model Drug into Injectable Microparticles Prepared Using Solvent Evaporation and Phase Separation Techniques

Article Article scientifique Article Factors Influencing the Entrapment of a Water Soluble Model Drug into Injectable Microparticles Prepared Using Solvent Evaporation and Phase Separation Techniques eng 1994 author Aftabroushad Shahrzad 24329 author Doelker Eric 25151 237-242 0939-6411 Microparticles of poly(ε-caprolactone) loaded with riboflavine sodium phosphate (0.5%) were produced by two different techniques, namely by solvent evaporation and phase separation. Our investigations were mainly concerned with the effect of various manufacturing and formulation parameters on the properties of the particles obtained and, in particular, on their size distribution and shape and on the entrapment ratio of the model drug. The respective advantages of the two techniques are discussed. Microparticles Microspheres Microcapsules Water-soluble drugs Riboflavine sodium phosphate Biodegradable polymers Solvent evaporation technique Phase separation technique Poly(ε-caprolactone) Dewey 615 31 Section des sciences pharmaceutiques 17 false European journal of pharmaceutics and biopharmaceutics 40 4 05aa2779-8e53-4e09-9eaa-1c2f50ea42c7 Article (Published version) Public Aftabroushad_EJPB_199440237.pdf 4456789 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Factors Influencing the Entrapment of a Water Soluble Model Drug into Injectable Microparticles Prepared Using Solvent Evaporation and Phase Separation Techniques	European journal of pharmaceutics and biopharmaceutics			1994	136	145

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Aftabroushad, Shahrzad