Connexins and secretion

Article Article scientifique Revue de la littérature Connexins and secretion eng 2002-11 author Serre Beinier Véronique 0000-0002-6016-1645 Department of Morphology, University of Geneva, Medical School, C.M.U., 1 rue Michel Servet, 1211 4, Genève, Switzerland. 123229 Département de chirurgie (CHIRU) author Mas Christophe 515567 author Calabrese Alessandra 508975 author Caton David 127297 author Cicchini-Bauquis Juliette 87097 author Rigo Dorothée 126299 Département de physiologie cellulaire et métabolisme (PHYME) author Charollais Anne 23109 author Cirulli Vincenzo 23915 author Meda Paolo 26346 477-492 10.1016/s0248-4900(02)00024-2 12566221 0248-4900 https://onlinelibrary.wiley.com/doi/10.1016/S0248-4900%2802%2900024-2 Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit, contribute to control the growth of secretory cells, their expression of specific genes and their differentiated function, including their characteristic ability to biosynthetize and release secretory products in a regulated manner. Since the previous reviews which have been published on this topic, several lines of evidence have been added in support of multiple regulatory roles of gland connexins. Here, we review this novel evidence, point to the many questions which are still open and discuss some interesting perspectives of the field. Animals Cell Communication / physiology Connexins / metabolism Connexins / physiology Endocrine Glands / chemistry Endocrine Glands / cytology Endocrine Glands / metabolism Exocrine Glands / chemistry Exocrine Glands / cytology Exocrine Glands / metabolism Gap Junctions / metabolism Gap Junctions / physiology Humans Dewey 616 Swiss National Science Foundation Endocrine function: elucidating the connexin-dependent pathway 67788 CH Projects 56 Département de médecine 221 false Biology of the cell 94 7-8 ff09a39b-efca-44d6-bd2d-889335133d6d Article (Published version) Restricted file.pdf 406312 application/pdf bb4e01efc73a47f7a28bfcf4f977df537344b3389fc70270e892e2a9e3b8b728 restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Connexins and secretion	Biology of the cell			2002	16	0

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Cirulli, Vincenzo