Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes

Article Article scientifique Article Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes eng 2000 author Eliez Stéphan 39336 author Palacio-Espasa Francisco 22883 author Spira A. author Lacroix M. author Pont C. author Luthi F. author Robert-Tissot Christiane 21869 author Feinstein C. author Schorderet D. F. author Antonarakis Stylianos 22813 author Cramer B. 109-114 10926060 1018-8827 http://www.springerlink.com/content/vjepc0xtrk5vt8mj/fulltext.pdf This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for individuals with this chromosomal deletion led us to examine the psychiatric and cognitive status of young children with VCFS. Our observations suggest a phenotype comprised of a borderline to mildly retarded level of intellectual functioning, a language delay, a general deficit in social initiation, difficulties with attention/concentration, and a perturbed train of thought. Child, Preschool Craniofacial Abnormalities/complications Female Heart Defects, Congenital/complications Humans Language Male Mental Disorders/ etiology Phenotype Speech Syndrome Dewey 616 56 Département de médecine 221 false European child & adolescent psychiatry 9 2 aba292d5-0bc4-4d5f-91b3-ea31f703f5ed Article Restricted file1.pdf 78503 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Young children with Velo-Cardio-Facial syndrome (CATCH-22). Psychological and language phenotypes	European child & adolescent psychiatry			2000	651	0

Archive ouverte UNIGE

Robert-Tissot, Christiane