Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

Article Article scientifique Article Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma eng 2011 author Perroud Nader Ali 0000-0002-9282-9216 94458 author Giacobino Ariane 28204 author Prada Paco Boris 506849 author Olié E author Salzmann Annick 0000-0003-0571-251X 510521 author Nicastro Rosetta 58466 author Guillaume S author Mouthon-Mermoud Dominique 135722 author Stouder Christelle 593405 author Dieben Karen 106571 author Huguelet Philippe 32349 author Courtet P author Malafosse Alain 111681 e59 10.1038/tp.2011.60 22832351 2158-3188 Childhood maltreatment, through epigenetic modification of the glucocorticoid receptor gene (NR3C1), influences the hypothalamic-pituitary-adrenal axis (HPA axis). We investigated whether childhood maltreatment and its severity were associated with increased methylation of the exon 1(F) NR3C1 promoter, in 101 borderline personality disorder (BPD) and 99 major depressive disorder (MDD) subjects with, respectively, a high and low rate of childhood maltreatment, and 15 MDD subjects with comorbid post-traumatic stress disorder (PTSD). Childhood sexual abuse, its severity and the number of type of maltreatments positively correlated with NR3C1 methylation (P=6.16 × 10(-8), 5.18 × 10(-7) and 1.25 × 10(-9), respectively). In BPD, repetition of abuses and sexual abuse with penetration correlated with a higher methylation percentage. Peripheral blood might therefore serve as a proxy for environmental effects on epigenetic processes. These findings suggest that early life events may permanently impact on the HPA axis though epigenetic modifications of the NR3C1. This is a mechanism by which childhood maltreatment may lead to adulthood psychopathology. Dewey 616.89 60 Département de psychiatrie 225 false 580 Groupe Giacobino Ariane (génétique) 923 4 Génétique psychiatrique 4 416 Psychiatrie communautaire 688 Translational psychiatry 1 905903cb-a136-4acb-ac95-da868437bb4e Article (Published version) Restricted tp201160a.pdf 466486 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma	Translational psychiatry			2011	1,463	0

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Mouthon-Mermoud, Dominique