5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives

Article Article scientifique Revue de la littérature 5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives eng 2006-03-16 2006 author Fotinos Nicolas 135662 author Campo Molina Marino Andres 618771 author Popowycz Florence 135683 author Gurny Robert 24779 Administration de la faculté des sciences (SIAD) author Lange Norbert 135650 Section des sciences pharmaceutiques (FARMA) 994-1015 10.1562/2006-02-03-IR-794 16542112 0031-8655 <p>The introduction of lipophilic derivatives of the naturally occurring heme precursor 5‐aminolevulinic acid (5‐ALA) into photomedicine has led to a true revival of this research area. 5‐ALA‐mediated photodynamic therapy (PDT) and fluorescence photodetection (FD) of neoplastic disease is probably one of the most selective cancer treatments currently known in oncology. To date, this method has been assessed experimentally for the treatment of various medical indications. However, the limited local bioavailability of 5‐ALA has widely prevented its use in daily clinical practice. Although researchers were already aware of this drawback early during the development of 5‐ALA‐mediated PDT, only recently have well‐established concepts in pharmaceutical science been adapted to investigate ways to overcome this drawback. Recently, two derivatives of 5‐ALA, methylaminolevulinate (MAL) and hexylaminolevulinate (HAL), gained marketing authorization from the regulatory offices in Europe and Australia. MAL is marketed under the trade name Metvix for the treatment of actinic keratosis and difficult‐to‐treat basal cell carcinoma. HAL has recently been launched under the trade name Hexvix to improve the detection of superficial bladder cancer in Europe. This review will first present the fundamental concepts underlying the use of 5‐ALA derivatives in PDT and FD from a chemical, biochemical and pharmaceutical point of view. Experimental evidences from preclinical data on the improvements and limits observed with 5‐ALA derivatives will then be introduced. The state‐of‐the‐art from clinical studies with 5‐ALA esters will be discussed, with special emphasis placed on the process that led to the development of MAL in dermatology and to HAL in urology. Finally, we will discuss promising medical fields in which use of 5‐ALA derivatives might potentially lead to further use of this methodology in photomedicine.</p> Dewey 615 31 Section des sciences pharmaceutiques 17 false Photochemistry and photobiology 82 4 c22e329b-aea0-41de-8c08-d058c33fec8e Article (Published version) Restricted Fotinos_PHPH_200682994.pdf 2737789 application/pdf 6d377797550a104ed03f887eb5f24ffa7421c3e3b552e542d2f0f64ec8873462 restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives	Photochemistry and photobiology			2006	99	0

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