Hemispheric specialization of the basal ganglia during vocal emotion decoding: evidence from asymmetric Parkinson's disease and 18 FDG PET

Article Article scientifique Article Hemispheric specialization of the basal ganglia during vocal emotion decoding: evidence from asymmetric Parkinson's disease and 18 FDG PET fre 2018 author Stirnimann Nancy 829092 author N'Diaye Karim author Le Jeune Florence author Houvenaghel Jean-François author Robert Gabriella 133925 author Drapier Sophie author Drapier Dominique author Grandjean Didier Maurice 502006 author Vérin Marc author Peron Julie Anne 705680 10.1016/j.neuropsychologia.2018.07.023 0028-3932 https://linkinghub.elsevier.com/retrieve/pii/S0028393218303749 The possible hemispheric specialization of the basal ganglia during emotional prosody (i.e., vocal emotion) processing has still to be elucidated. Coupled with affective measures and neuroimaging, Parkinson's disease offers a unique opportunity to study this question, on account of its characteristically asymmetric striatal dysfunction, which translates into predominantly contralateral motor symptoms. We investigated the cerebral metabolic bases of emotional prosody recognition in patients with Parkinson's disease with left- versus right-lateralized motor symptoms, postulating that patients with greater right hemispheric brain dysfunction have a specific impairment that correlates with the metabolic modification of a brain network known to be involved in emotional prosody. A total of 38 patients performed a validated emotional prosody recognition task and underwent a resting-state F-18 fluorodeoxyglucose PET scan, as well as clinical, motor, neuropsychological, and psychiatric assessments. Patients' performances were compared with those of 45 healthy controls. As expected, vocal emotion recognition was significantly poorer among patients with left-sided motor symptoms than among both right-sided patients and controls. There was no significant difference between right-sided patients and controls. This effect was observed for both the total score and the happiness subscore. Interestingly, regressions showed that the greater the emotional misattribution, the greater the patients' age and asymmetric motor symptom severity. Finally, at the metabolic level, positive correlations were found between the happiness recognition subscore and the metabolism of the right orbitofrontal cortex in patients with left-sided motor symptoms. A right orbitofrontal-basal ganglia coupling seems to be specifically involved in the vocal emotion recognition deficit observed in Parkinson's disease. The asymmetry of motor symptoms is thus an important clinical factor, in that it may influence the presence or severity of affective disorders in Parkinson's disease. Parkinson's disease Asymmetry Emotional prosody Striatum Dewey 128.37 Dewey 150 15 Centre interfacultaire en sciences affectives 0D8 108 Section de psychologie 71 false 1241 Affective sciences 594 Neuroscience de l'émotion et dynamiques affectives (NEAD) Neuropsychologia 8ddee230-38ba-412e-abe6-5a223e204439 Article (Accepted version) Public redepotmain.pdf 1240526 application/pdf openAccess Centres et instituts / Centre interfacultaire en sciences affectives Faculté de psychologie et des sciences de l'éducation / Section de psychologie

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Hemispheric specialization of the basal ganglia during vocal emotion decoding: evidence from asymmetric Parkinson's disease and 18 FDG PET	Neuropsychologia			2018	654	780

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