Determinants of infant responses to vaccines in presence of maternal antibodies

Article Article scientifique Article Determinants of infant responses to vaccines in presence of maternal antibodies eng 1998 author Siegrist Claire-Anne 26816 author Cordova Mesa Marco 501807 author Brandt-Schaichet Catheine 128479 author Barrios-Janko Christy 29627 author Berney Monika 25917 author Tougne Chantal 23068 author Kovarik Jiri 114989 author Lambert Paul Henri 25121 1409-1414 10.1016/S0264-410X(98)00100-5 9711780 0264-410X Presence of maternally-derived antibodies at time of immunization is known to often interfere with active infant immunization, although with variable degrees of clinical significance. In order to progressively decipher the rules that form the basis for these inhibitory effects on infant vaccine responses, two antigens (measles, tetanus) and various antigen presentation systems were evaluated in murine early life immunization models either in absence or presence of maternal antibodies. Both conventional (proteins, conjugate vaccines) and new (live viral vectors, DNA plasmids) antigen presentation systems were found to be similarly susceptible to the inhibitory influence of maternal antibodies. Factors emerging as crucial determinants of maternal antibody-mediated effects on responses to both live and non-live vaccines include (i) the level of maternal antibodies present at immunization, (ii) the use of distinct vaccines in mothers and pups and (iii) their distinct influence on B cell and T cell vaccine responses. Animals Antibodies, Bacterial/immunology Antibodies, Viral/immunology Antigen Presentation/immunology Antigens/immunology B-Lymphocytes/immunology Female Immunity, Maternally-Acquired/immunology Lymphocyte Activation/immunology Mice Mice, Inbred BALB C T-Lymphocytes/immunology Tetanus Toxoid/immunology/pharmacology Vaccines/immunology/pharmacology Vaccines, Conjugate/immunology/pharmacology Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 false 143 Centre de Vaccinologie et d'Immunologie néonatale 177 Vaccine 16 14-15 b680efe4-1bac-4b31-bd50-5201a869b80a Article (Published version) Restricted 1409-1414.pdf 769373 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Determinants of infant responses to vaccines in presence of maternal antibodies	Vaccine			1998	487	0

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Brandt-Schaichet, Catheine