A Positive Feedback Loop between ATOH7 and a Notch Effector Regulates Cell-Cycle Progression and Neurogenesis in the Retina

Article Article scientifique Article A Positive Feedback Loop between ATOH7 and a Notch Effector Regulates Cell-Cycle Progression and Neurogenesis in the Retina eng 2013 author Chiodini Florence 30216 author Matter-Sadzinski Lidia 24134 author Rodrigues Tania 632076 author Skowronska-Krawczyk Dorota 126874 author Brodier Laurent 654411 author Schaad Olivier 0000-0003-1576-783X 23118 author Bauer Christoph Ruediger 134757 author Ballivet Marc 24708 author Matter Jean-Marc 26476 796-807 10.1016/j.celrep.2013.01.035 23434507 2211-1247 http://linkinghub.elsevier.com/retrieve/pii/S2211124713000594 The HES proteins are known Notch effectors and have long been recognized as important in inhibiting neuronal differentiation. However, the roles that they play in the specification of neuronal fate remain largely unknown. Here, we show that in the differentiating retinal epithelium, the proneural protein ATOH7 (ATH5) is required for the activation of the transcription of the Hes5.3 gene before the penultimate mitosis of progenitor cells. We further show that the HES5.3 protein slows down the cell-cycle progression of Atoh7-expressing cells, thereby establishing conditions for Atoh7 to reach a high level of expression in S phase and induce neuronal differentiation prior to the ultimate mitosis. Our study uncovers how a proneural protein recruits a protein known to be a component of the Notch signaling pathway in order to regulate the transition between an initial phase of selection among uncommitted progenitors and a later phase committing the selected progenitors to neuronal differentiation. Dewey 540 39 Département de biochimie 144 false Cell reports 3 3 708743c3-62ea-4632-ad97-a1bdc0d2ec20 Article (Published version) Public Chiodini.pdf 1865752 application/pdf openAccess Faculté des sciences / Section de chimie et biochimie / Département de biochimie

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A Positive Feedback Loop between ATOH7 and a Notch Effector Regulates Cell-Cycle Progression and Neurogenesis in the Retina	Cell reports			2013	770	348

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Skowronska-Krawczyk, Dorota