Simulations of temperature sensitivity of the peroxidase

Article Article scientifique Article Simulations of temperature sensitivity of the peroxidase–oxidase oscillator eng 2002 author Valeur Kirsten 108298 author Degli Agosti Robert 26498 259-270 10.1016/S0301-4622(02)00226-0 0301-4622 http://linkinghub.elsevier.com/retrieve/pii/S0301462202002260 The influence of temperature on the oscillatory kinetics of the peroxidase-oxidase reaction was studied theoretically. Assuming Q10=2 for elementary reactions, the effect of multiplying the rate constants of the model by factors between 0.5 and 2 (corresponding to a 10 °C decrease and increase, respectively, of temperature) was investigated. First, the individual rate constants were successively multiplied by 0.5 or 2 while all other rate constants were kept unchanged. This resulted in either a longer or a shorter period, depending on the rate constant being changed. Multiplication by 0.5 or by 2 generally resulted in opposite effects on the period length. However, the absolute value of this deviation differed. Also, the dynamics changed when halving the dimerization rate of NAD+ as wail as when doubling the rate constant for the reduction of ferric peroxidase by NAD+. Next, simulations were performed multiplying all rate constants by one and the same factor, which increased progressively from 0.5 to 2. Intervals were found corresponding to temperature dependency, compensation, and over-compensation, respectively. Peroxidase-oxidase Temperature compensation Model Simulation Oscillation Dewey 550 41 Département F.-A. Forel des sciences de l'environnement et de l'eau 153 false Biophysical chemistry 99 3 ee5ff3d6-9782-4175-ac83-b9d35f5ff568 Article (Published version) Restricted 00CC48t.pdf 1423164 application/pdf restrictedAccess Faculté des sciences / Section des sciences de la Terre et de l'Environnement / Département F.-A. Forel des sciences de l'environnement et de l'eau

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Simulations of temperature sensitivity of the peroxidase–oxidase oscillator	Biophysical chemistry			2002	615	0

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Valeur, Kirsten