Biliary atresia and orthotopic liver transplantation. 11 years of experience in Geneva

Article Article scientifique Article Biliary atresia and orthotopic liver transplantation. 11 years of experience in Geneva eng 2001 author Le Coultre Claude Pierrette 24018 author Battaglin Céline 41339 author Bugmann Philippe 61705 author Genin Bernard 34808 author Bachmann Roger 107167 author Mclin Valérie Anne 799651 author Mentha Gilles 22892 author Belli Dominique Charles 26369 199-204 10.1024/1023-9332.7.5.199 11678017 1023-9332 Biliary atresia (BA) is a congenital malformation or an evolutive inflammatory process which, without treatment, leads to cirrhosis, hepatic failure and death within two years of birth. The literature gives a survival rate of 60% at five years and 25% to adulthood after an initial operation performed for BA. 30% of children do not survive beyond two years of age. BA has become the most frequent indication for liver transplantation (LT) in children. With LT, survival expectancy is 90%. Results of the operation designed for BA remain unsatisfactory, and seem to depend on the age of the infants, as well as on other factors such as liver histology, and centre experience. Since 1989, onset of the paediatric hepatic transplantation program in Geneva, to July 2000, 20 children have been referred for initial treatment of BA, and 26 for possible hepatic transplantation after initial treatment done in another centre. The aim of the current study is to analyse our own results of the initial operation and to present the results of liver transplantation in this particular group of patients. All the patients with a BA are included in this study. The initial operation for BA yielded 43% favourable outcome at five years and the survival in this group following LT reached 91.3% survival. The importance of the age of the patient at time of initial operation is underlined. Biliary Atresia/mortality/surgery Child Child, Preschool Female Follow-Up Studies Humans Infant Liver Function Tests Liver Transplantation Male Postoperative Complications/mortality/surgery Reoperation Survival Rate Dewey 617 Dewey 618 57 Département de chirurgie 222 58 Département de pédiatrie, gynécologie et obstétrique 223 false 147 Gastroentérologie et transplantation (pédiatrie) 181 249 Hépatologie chirurgicale 327 Swiss surgery 7 5 97f0dfc3-4da8-4b29-b966-cc67bac985ff Article (Published version) Restricted 2001_le_coultre_swiss_surg.pdf 774543 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Biliary atresia and orthotopic liver transplantation. 11 years of experience in Geneva	Swiss surgery			2001	630	1

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Bachmann, Roger