Venlafaxine versus applied relaxation for generalized anxiety disorder: a randomized controlled study on clinical and electrophysiological outcomes

Article Article scientifique Article Venlafaxine versus applied relaxation for generalized anxiety disorder: a randomized controlled study on clinical and electrophysiological outcomes eng 2015 author Zullino Daniele Fabio 649976 author Chatton Anne 54835 author Fresard Emmanuelle 506756 author Stankovic Miroslava 104540 author Bondolfi Guido 135439 author Borgeat François author Khazaal Yasser 668423 69-82 10.1007/s11126-014-9334-2 25464934 0033-2720 Some components of generalized anxiety disorder, such as physical symptoms, are thought to reflect autonomic nervous system arousal. This study primarily assessed the relationships between psychophysiological and clinical measures using venlafaxine extended release or applied relaxation, and secondarily, the impact of combination treatment in patients not remitting after 8 weeks. Fifty-eight patients were randomly assigned to 8 weeks of treatment with either venlafaxine or applied relaxation (Phase I). Non-remitted patients received combination treatment for an additional 8 weeks (Phase II). Assessments included the Hamilton Anxiety Scale (HAM-A), Beck Depression Inventory, Penn State Worry Questionnaire and the Stroop Color-Word Task coupled with electrophysiological measures (skin conductance and frontalis electromyography (EMG)). In Phase 1, a time effect was found for the clinical and skin conductance measures. Thirteen patients from each group were in remission. In Phase 2, seven additional patients remitted. Baseline psychophysiological measures were not associated with baseline clinical variables or with clinical outcomes. Independently of treatment allocation, a reduction in frontal EMG values at week 4 was significantly associated with a decrease in HAM-A scores at week 8. At week 4, responders from the applied relaxation group had lower electrophysiological activity than the venlafaxine group. Baseline psychophysiological measures were not linked with clinical measures at study inclusion or with treatment response. Frontal EMG response at week 4 is a possible predictor of treatment response. Treatment combination enhances treatment response after initial failure. Dewey 616.89 60 Département de psychiatrie 225 false 496 Abus de substances 834 418 Médecine psychosomatique, neurosciences cliniques et mindfulness 690 Psychiatric quarterly 86 1 00032c29-cf1b-4819-873f-719e153bb420 Article (Published version) Restricted Zullino_PsychiatrQ_2015.pdf 287430 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Venlafaxine versus applied relaxation for generalized anxiety disorder: a randomized controlled study on clinical and electrophysiological outcomes	Psychiatric quarterly			2015	600	0

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Stankovic, Miroslava